Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases (Q44378329)

2 December 2017

Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases (English)

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2 December 2017

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Ping Huang

1

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2 December 2017

John Ramphal

2

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2 December 2017

James Wei

3

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2 December 2017

Congxin Liang

4

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2 December 2017

Bahija Jallal

5

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2 December 2017

Gerald McMahon

6

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2 December 2017

Cho Tang

7

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2 December 2017

language of work or name

English

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publication date

1 April 2003

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Bioorganic & Medicinal Chemistry

2 December 2017

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2 December 2017

11

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2 December 2017

8

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2 December 2017

1835-1849

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Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes

2 December 2017

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https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Protein tyrosine phosphatases: mechanisms of catalysis and regulation

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https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

From form to function: signaling by protein tyrosine phosphatases.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of human protein tyrosine phosphatase 1B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

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https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of the tandem phosphatase domains of RPTP LAR

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of the tyrosine phosphatase SHP-2

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of the dual specificity protein phosphatase VHR

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of bovine heart phosphotyrosyl phosphatase at 2.2-A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of bovine low molecular weight phosphotyrosyl phosphatase complexed with the transition state analog vanadate

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

The structure of the bovine protein tyrosine phosphatase dimer reveals a potential self-regulation mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Crystal structures of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Protein-tyrosine phosphatases: structure, mechanism, and inhibitor discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Structure-based design and synthesis of small molecule protein-tyrosine phosphatase 1B inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Potent non-peptidyl inhibitors of protein tyrosine phosphatase 1B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

[Difluro(phosphono)methyl]phenylalanine-containing peptide inhibitors of protein tyrosine phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Synthesis and biological evaluation of alpha,alpha-difluorobenzylphosphonic acid derivatives as small molecular inhibitors of protein-tyrosine phosphatase 1B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Nitroarylhydroxymethylphosphonic acids as inhibitors of CD45.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Potent inhibition of protein-tyrosine phosphatase-1B using the phosphotyrosyl mimetic fluoro-O-malonyl tyrosine (FOMT)

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Mapping the subsite preferences of protein tyrosine phosphatase PTP-1B using combinatorial chemistry approaches.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases

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https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Inhibition of protein tyrosine phosphatases PTP1B and CD45 by sulfotyrosyl peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Potent reversible inhibitors of the protein tyrosine phosphatase CD45.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Structure-based discovery of small molecule inhibitors targeted to protein tyrosine phosphatase 1B

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Why is phosphonodifluoromethyl phenylalanine a more potent inhibitory moiety than phosphonomethyl phenylalanine toward protein-tyrosine phosphatases?

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

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https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900039-7

7 January 2021

10.1016/S0968-0896(03)00039-7

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