The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells. (Q44319734)

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31 October 2019

title

The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells (English)

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31 October 2019

5

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31 October 2019

author name string

Bolick SC

1

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31 October 2019

Landowski TH

2

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31 October 2019

Boulware D

3

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31 October 2019

Oshiro MM

4

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Hamilton AD

6

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Sebti SM

7

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Dalton WS

8

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publication date

1 February 2003

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31 October 2019

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volume

17

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31 October 2019

page(s)

451-457

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31 October 2019

issue

2

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2402832

31 October 2019

exact match

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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

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Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

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Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

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