Deleterious network hypothesis of Alzheimer's disease (Q44245798)

1 December 2017

Deleterious network hypothesis of Alzheimer's disease (English)

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deleterious network hypothesis

1 December 2017

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Ying W

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1 December 2017

1 May 1996

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1 December 2017

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1 December 2017

46

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5

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1 December 2017

421-428

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Advances in Alzheimer's disease

1 December 2017

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

The risk factors for Alzheimer's disease: a review and a hypothesis

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

A prospective study of Alzheimer disease in Down syndrome.

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration.

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Hydrogen peroxide mediates amyloid beta protein toxicity

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Hydroperoxide metabolism in mammalian organs

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Neuronal lipofuscin accumulation in ageing and alzheimer dementia: a pathogenic mechanism?

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: prevention by NGF and bFGF

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Cephaloconiosis: a free radical perspective on the proposed particulate-induced etiopathogenesis of Alzheimer's dementia and related disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Involvement of free oxygen radicals in beta-amyloidosis: an hypothesis

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Effect of reactive oxygen species on the erythrocyte calcium-pump function in protein-energy malnutrition

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

The hydroperoxide-induced release of mitochondrial calcium occurs via a distinct pathway and leaves mitochondria intact

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Mitochondria from Alzheimer's fibroblasts show decreased uptake of calcium and increased sensitivity to free radicals.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Effect of ligands on the reactivity of essential sulfhydryls in brain hexokinase. Possible interaction between substrate binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Influence of the rebox state of glutathione upon pyruvate kinase in the intact erythrocyte

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Neurodegeneration, Alzheimer's disease, and beta-amyloid toxicity

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Inhibition of beta-amyloid production by activation of protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Susceptibility of protein kinase C to oxidative inactivation: loss of both phosphotransferase activity and phorbol diester binding

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

In vitro polymerization of oxidized tau into filaments.

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Amyloid beta peptide induces necrosis rather than apoptosis.

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Activation of oncogenes and/or inactivation of anti-oncogenes by reactive oxygen species

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Increased frequency of the transferrin C2 subtype in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Altered brain metabolism of iron as a cause of neurodegenerative diseases?

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Abnormalities in brain glucose utilization and its impact on cellular and molecular mechanisms in sporadic dementia of Alzheimer type.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Abnormalities of Energy Metabolism in Alzheimer's Disease Studied with PETa

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Abnormalities of Glucose Metabolism in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Electron transport chain defects in Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Changes in brain glucose metabolism as a key to the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

The mnemon and its juices: neuromodulation of memory processes

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Alzheimer's disease and malnutrition: A new etiological hypothesis

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients.

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Clinical risk factors for Alzheimer's disease: a population-based case-control study.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Women, myocardial infarction, and dementia in the very old.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Calcium as sculptor and destroyer of neural circuitry

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Identification of an NADH plus iron dependent, Ca2+ activated hydrogen peroxide production in synaptosomes

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Isolated cerebral and cerebellar mitochondria produce free radicals when exposed to elevated CA2+ and Na+: implications for neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Calcium enhances in vitro free radical-induced damage to brain synaptosomes, mitochondria, and cultured spinal cord neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Calcium-mediated processes in neuronal degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Calcium ionophore increases amyloid beta peptide production by cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Calcium signaling in neurons: molecular mechanisms and cellular consequences

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Comparison of the effects of elevated intracellular aluminum and calcium levels on neuronal survival and tau immunoreactivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Medical history and the risk of Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Action of amyloid beta-protein on protein kinase C activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Effects of Alzheimer's disease-related beta amyloid protein fragments on enzymes metabolizing phosphoinositides in brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Activation of macrophages by Alzheimer beta amyloid peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0306-9877%2896%2990021-3

7 January 2021

10.1016/S0306-9877(96)90021-3

Identifiers

DOI

1 reference

1 December 2017

1 reference

PubMed ID

8735880