A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571. (Q44219205)

30 November 2017

A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571. (English)

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30 November 2017

Frank D Böhmer

1

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30 November 2017

Luchezar Karagyozov

2

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30 November 2017

Andrea Uecker

3

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30 November 2017

Hubert Serve

4

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30 November 2017

Alexander Botzki

5

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30 November 2017

Siavosh Mahboobi

6

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30 November 2017

Stefan Dove

7

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30 November 2017

language of work or name

English

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publication date

14 November 2002

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Journal of Biological Chemistry

30 November 2017

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30 November 2017

278

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30 November 2017

5148-5155

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30 November 2017

7

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Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

30 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209861200

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

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1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209861200

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209861200

STI571: a paradigm of new agents for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209861200

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209861200

Involvement of platelet-derived growth factor in disease: development of specific antagonists

21 January 2018

1 reference

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Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins

21 January 2018

1 reference

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A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209861200

Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase

21 January 2018

1 reference

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Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase

21 January 2018

1 reference

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

1 reference

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Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3.

21 January 2018

1 reference

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Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction

21 January 2018

1 reference

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Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296.

21 January 2018

1 reference

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18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design

21 January 2018

1 reference

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Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

21 January 2018

1 reference

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

21 January 2018

1 reference

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

21 January 2018

1 reference

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A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

21 January 2018

1 reference

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Acquisition of inhibitor-sensitive protein kinases through protein design

21 January 2018

1 reference

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Magic bullets for protein kinases

21 January 2018

1 reference

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Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

21 January 2018

1 reference

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Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase.

21 January 2018

1 reference

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

21 January 2018

1 reference

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209861200

Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209861200

Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor

21 January 2018

1 reference

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Structural basis for selective inhibition of Src family kinases by PP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209861200

21 January 2018

Identifiers

DOI

10.1074/JBC.M209861200

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30 November 2017

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