Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling (Q44123776)

30 November 2017

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling (English)

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Douglas J Hilton

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Donald Metcalf

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object named as

Donald Metcalf

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Tracy A Willson

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Louis J Fabri

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Christopher J Greenhalgh

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object named as

Christopher J Greenhalgh

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Jason E Corbin

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Anne L Thaus

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Phillip O Morgan

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Jian-Guo Zhang

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Helene M Martin

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Manuel Baca

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Warren S Alexander

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language of work or name

English

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publication date

2 September 2002

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Journal of Biological Chemistry

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277

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40181-40184

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43

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Negative regulation of cytokine signaling pathways

30 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.C200450200

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C200450200

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C200450200

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C200450200

Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

Stat5a is mandatory for adult mammary gland development and lactogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

Gigantism in mice lacking suppressor of cytokine signalling-2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C200450200

Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C200450200

Lack of Socs2 expression causes the high-growth phenotype in mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C200450200

Growth Enhancement in Suppressor of Cytokine Signaling 2 (SOCS-2)-Deficient Mice Is Dependent on Signal Transducer and Activator of Transcription 5b (STAT5b)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C200450200

Functional analysis of Asb-1 using genetic modification in mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C200450200

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

Mutation of the SHP-2 Binding Site in Growth Hormone (GH) Receptor Prolongs GH-Promoted Tyrosyl Phosphorylation of GH Receptor, JAK2, and STAT5B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200450200

21 January 2018

Identifiers

DOI

10.1074/JBC.C200450200

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30 November 2017

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