Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form (Q44088944)

29 November 2017

Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form (English)

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29 November 2017

2

Neil R Cashman

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29 November 2017

Wen-Quan Zou

1

1 reference

PubMed ID

12161431

29 November 2017

language of work or name

English

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publication date

2 August 2002

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Journal of Biological Chemistry

29 November 2017

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29 November 2017

277

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29 November 2017

46

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29 November 2017

43942-43947

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29 November 2017

Prion Protein Biology

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https://api.crossref.org/works/10.1074%2FJBC.M203611200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Cell-free formation of protease-resistant prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Cell-lysate conversion of prion protein into its protease-resistant isoform suggests the participation of a cellular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

A scrapie-like unfolding intermediate of the prion protein domain PrP(121-231) induced by acidic pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

All or none fibrillogenesis of a prion peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Cellular prion proteins of mammalian species display an intrinsic partial proteinase K resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Immobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Monoclonal antibodies specific for the native, disease-associated isoform of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Conformational change, aggregation and fibril formation induced by detergent treatments of cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Structural intermediates in the putative pathway from the cellular prion protein to the pathogenic form.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Scrapie infectivity found in resistant species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Long-term subclinical carrier state precedes scrapie replication and adaptation in a resistant species: analogies to bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Mapping the early steps in the pH-induced conformational conversion of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Conformational transitions in peptides containing two putative alpha-helices of the prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Pathologic conformations of prion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Electron paramagnetic resonance evidence for binding of Cu(2+) to the C-terminal domain of the murine prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Scrapie prion protein contains a phosphatidylinositol glycolipid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Endosome-lysosomes and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

A role for destabilizing amino acid replacements in light-chain amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Human lysozyme gene mutations cause hereditary systemic amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Synthesis and trafficking of prion proteins in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Immunoreactivity to ubiquitin-protein conjugates is present early in the disease process in the brains of scrapie-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

The abnormal isoform of the prion protein accumulates in late-endosome-like organelles in scrapie-infected mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Multiple folding pathways for heterologously expressed human prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M203611200

21 January 2018

Identifiers

DOI

10.1074/JBC.M203611200

1 reference

29 November 2017

1 reference

PubMed ID

12161431