Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. (Q44058777)

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2 January 2020

title

Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization (English)

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4

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author name string

Yasuhiro Koh

1

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2 January 2020

Shintaro Matsumi

2

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2 January 2020

Debananda Das

3

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2 January 2020

David A Davis

5

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2 January 2020

Jianfeng Li

6

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2 January 2020

Sofiya Leschenko

7

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Abigail Baldridge

8

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2 January 2020

Tatsuo Shioda

9

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2 January 2020

Robert Yarchoan

10

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Arun K Ghosh

11

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Hiroaki Mitsuya

12

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language of work or name

English

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publication date

17 July 2007

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Journal of Biological Chemistry

2 January 2020

published in

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volume

282

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issue

39

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page(s)

28709-28720

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HIV-1 dynamics in vivo: implications for therapy

2 January 2020

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The folding and dimerization of HIV-1 protease: evidence for a stable monomer from simulations

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Switching between allosteric and dimerization inhibition of HIV-1 protease

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Disruption of the HIV-1 protease dimer with interface peptides: structural studies using NMR spectroscopy combined with [2-(13)C]-Trp selective labeling.

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Inhibition of HIV-1 replication by a peptide dimerization inhibitor of HIV-1 protease.

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Interaction of the bacteriophage P1 recombinase Cre with the recombining site loxP

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PCR-mediated recombination: a general method applied to construct chimeric infectious molecular clones of plasma-derived HIV-1 RNA.

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Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors

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Fluorescence resonance energy transfer (FRET) microscopy imaging of live cell protein localizations

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Microspectroscopic imaging tracks the intracellular processing of a signal transduction protein: fluorescent-labeled protein kinase C beta I

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Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease

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Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114).

21 January 2018

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Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

21 January 2018

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Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114

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Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance

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Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.

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Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases

21 January 2018

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Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor

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Folded monomer of HIV-1 protease

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Revisiting monomeric HIV-1 protease. Characterization and redesign for improved properties

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M703938200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17635930%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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