eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides (Q43916748)

28 November 2017

eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides (English)

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28 November 2017

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James Ellis

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Philippe Leboulch

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Philippe Leboulch

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28 November 2017

Bruno Dalle

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28 November 2017

Joel E Rubin

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28 November 2017

Ozan Alkan

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28 November 2017

Tanya Sukonnik

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28 November 2017

Peter Pasceri

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28 November 2017

Shuyuan Yao

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Rob Pawliuk

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1 April 2005

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591-599

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Gene therapy for the hemoglobin disorders: past, present, and future

28 November 2017

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

The beta-globin locus control region versus gene therapy vectors: a struggle for expression.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Expression of a human beta-globin transgene in erythroid cells derived from retrovirally transduced transplantable human fetal liver and cord blood cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

The beta-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

DNA methylation patterns and epigenetic memory

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Primary structure of the Aequorea victoria green-fluorescent protein

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Optimized codon usage and chromophore mutations provide enhanced sensitivity with the green fluorescent protein

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Dynamic analysis of proviral induction and De Novo methylation: implications for a histone deacetylase-independent, methylation density-dependent mechanism of transcriptional repression

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Retroviral vector sequences inhibit human beta-globin gene expression in transgenic mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Retrovirus silencer blocking by the cHS4 insulator is CTCF independent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Correction of sickle cell disease in transgenic mouse models by gene therapy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Evaluation of beta-globin gene therapy constructs in single copy transgenic mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Production of high-titer helper-free retroviruses by transient transfection

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Episomal vectors rapidly and stably produce high-titer recombinant retrovirus

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Codon usage limitation in the expression of HIV-1 envelope glycoprotein

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Retroviral expression in embryonic stem cells and hematopoietic stem cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Mutation of CpGs in the murine stem cell virus retroviral vector long terminal repeat represses silencing in embryonic stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Development of virus vectors for gene therapy of beta chain hemoglobinopathies: flanking with a chromatin insulator reduces gamma-globin gene silencing in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.11.012

10.1016/J.YMTHE.2004.11.012

7 January 2021

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28 November 2017

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