Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions (Q43907613)

27 November 2017

Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions (English)

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27 November 2017

8

Maria Kavallaris

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27 November 2017

Nicole M Verrills

1

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27 November 2017

Claudia L Flemming

2

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27 November 2017

Marjorie Liu

3

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27 November 2017

Michael T Ivery

4

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27 November 2017

Gary S Cobon

5

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27 November 2017

Murray D Norris

6

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27 November 2017

Michelle Haber

7

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27 November 2017

1 July 2003

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27 November 2017

Chemistry and Biology

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27 November 2017

10

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27 November 2017

7

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27 November 2017

597-607

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The taxoids. Comparative clinical pharmacology and therapeutic potential

27 November 2017

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Mechanism of action of taxol

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

The epothilones, eleutherobins, and related types of molecules

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Anticancer therapy with novel tubulin-interacting drugs

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

A common pharmacophore for cytotoxic natural products that stabilize microtubules

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

A Common Pharmacophore for Taxol and the Epothilones Based on the Biological Activity of a Taxane Molecule Lacking a C-13 Side Chain†

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Mechanisms of action and resistance to tubulin-binding agents

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Structure of the alpha beta tubulin dimer by electron crystallography

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Microtubule structure at improved resolution

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

How Taxol stabilises microtubule structure.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Focusing-in on microtubules.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Substoichiometric binding of taxol suppresses microtubule dynamics.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

High-resolution model of the microtubule

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

A beta-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Altered expression of M beta 2, the class II beta-tubulin isotype, in a murine J774.2 cell line with a high level of taxol resistance

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Cytoskeleton: functions for tubulin modifications at last

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Removal of beta III isotype enhances taxol induced microtubule assembly.

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Tubulin isotypes and the multigene tubulin families

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Cross-species identification of proteins separated by two-dimensional gel electrophoresis using matrix-assisted laser desorption ionisation/time-of-flight mass spectrometry and amino acid composition.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Cross-matching marsupial proteins with eutherian mammal databases: proteome analysis of cells from UV-induced skin tumours of an opossum (Monodelphis domestica).

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

Characterization of differently processed forms of enolase 2 from Saccharomyces cerevisiae by two-dimensional gel electrophoresis and mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900141-8

7 January 2021

10.1016/S1074-5521(03)00141-8

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DOI

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27 November 2017

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