Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2). (Q43886305)

27 November 2017

Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2). (English)

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27 November 2017

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4

Olof Rådmark

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27 November 2017

3

Dieter Steinhilber

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27 November 2017

1

Oliver Werz

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27 November 2017

Dagmar Szellas

2

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PubMed ID

11844797

27 November 2017

language of work or name

English

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publication date

13 February 2002

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Journal of Biological Chemistry

27 November 2017

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27 November 2017

277

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27 November 2017

17

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27 November 2017

14793-14800

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Leukotrienes and lipoxins: structures, biosynthesis, and biological effects

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The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation

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Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase

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Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase

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5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

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Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes

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Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

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Inhibition of p38 MAP kinase as a therapeutic strategy

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Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type-specific activation of mitogen-activated protein kinases.

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Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway

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Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.

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MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo

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5-Lipoxygenase interacts with coactosin-like protein

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Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

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A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

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PRAK, a novel protein kinase regulated by the p38 MAP kinase

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Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites

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Inhibition by fatty acids of cyclic AMP-dependent protein kinase activity in brush border membranes isolated from human placental vesicles

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Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase

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The growing phospholipase A2 superfamily of signal transduction enzymes

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Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C.

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Arachidonic acid induces the activation of the stress-activated protein kinase, membrane ruffling and H2O2 production via a small GTPase Rac1.

21 January 2018

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Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death

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Protein kinase C: cellular target of the second messenger arachidonic acid?

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Group V phospholipase A(2)-mediated oleic acid mobilization in lipopolysaccharide-stimulated P388D(1) macrophages

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A Ca(2+)-independent activation of a type IV cytosolic phospholipase A(2) underlies the receptor stimulation of arachidonic acid-dependent noncapacitative calcium entry

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Arachidonic acid-induced mobilization of calcium in human neutrophils: evidence for a multicomponent mechanism of action

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Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2.

21 January 2018

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Regulation of protein kinase C betaII by its C2 domain

21 January 2018

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The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity

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The upstream regulation of p38 mitogen-activated protein kinase phosphorylation by arachidonic acid in rat neutrophils

21 January 2018

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Selenium-dependent peroxidases suppress 5-lipoxygenase activity in B-lymphocytes and immature myeloid cells. The presence of peroxidase-insensitive 5-lipoxygenase activity in differentiated myeloid cells

21 January 2018

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Activation of leukotriene synthesis in human neutrophils by exogenous arachidonic acid: inhibition by adenosine A(2a) receptor agonists and crucial role of autocrine activation by leukotriene B(4)

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Characterization of an acetyl-11-keto-beta-boswellic acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling

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Time-dependent utilization of platelet arachidonic acid by the neutrophil in formation of 5-lipoxygenase products in platelet-neutrophil co-incubations

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Differential metabolism of exogenous and endogenous arachidonic acid in human neutrophils

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The involvement of extracellular calcium in the formation of 5-lipoxygenase metabolites by human polymorphonuclear leukocytes

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The role of calcium and phosphorylation of cytosolic phospholipase A2 in regulating arachidonic acid release in macrophages

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21 January 2018

Identifiers

DOI

10.1074/JBC.M111945200

1 reference

27 November 2017

1 reference

PubMed ID

11844797