beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations (Q43823461)

27 November 2017

beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations (English)

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27 November 2017

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McPhie DL

1

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27 November 2017

Golde T

2

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27 November 2017

Eckman CB

3

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27 November 2017

Yager D

4

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27 November 2017

Brant JB

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27 November 2017

Neve RL

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27 November 2017

1 December 2001

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27 November 2017

Molecular Brain Research

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27 November 2017

97

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27 November 2017

103-113

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27 November 2017

1

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Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons.

27 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Generation of amyloid beta protein from its precursor is sequence specific

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Generation of beta A4 from the amyloid protein precursor and fragments thereof

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Ionic effects of the Alzheimer's disease beta-amyloid precursor protein and its metabolic fragments

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Alzheimer's disease. In search of gamma-secretase.

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Vaccine development for Alzheimer's disease: a shot of good news.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Caspase cleavage of APP results in a cytotoxic proteolytic peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Apoptosis and Alzheimer's Disease

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Isolation, cloning, and localization of rat PV-1, a novel endothelial caveolar protein

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

Amyloid beta vaccination: reduced plaques and improved cognition.

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https://api.crossref.org/works/10.1016%2FS0169-328X%2801%2900294-7

7 January 2021

10.1016/S0169-328X(01)00294-7

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27 November 2017

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