Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin alpha-sarcin (Q43815486)

27 November 2017

Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin alpha-sarcin (English)

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27 November 2017

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27 November 2017

Antonio Martínez Ruiz

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27 November 2017

Alvaro Martínez-del-Pozo

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27 November 2017

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27 November 2017

M Masip

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27 November 2017

J M Mancheño

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3

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27 November 2017

language of work or name

English

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publication date

1 December 2001

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27 November 2017

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27 November 2017

268

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23

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27 November 2017

6190-6196

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Specific cleavage of ribosomal RNA caused by alpha sarcin

27 November 2017

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Effect of alpha-sarcin and ribosome-inactivating proteins on the interaction of elongation factors with ribosomes

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Cytotoxic mechanism of the ribotoxin alpha-sarcin. Induction of cell death via apoptosis

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Study of the interaction between the antitumour protein alpha-sarcin and phospholipid vesicles

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Fusion of phospholipid vesicles produced by the anti-tumour protein alpha-sarcin

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Translocation of alpha-sarcin across the lipid bilayer of asolectin vesicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Sequence determination and molecular characterization of gigantin, a cytotoxic protein produced by the mould Aspergillus giganteus IFO 5818.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Ribotoxins are a more widespread group of proteins within the filamentous fungi than previously believed.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

The highly refined solution structure of the cytotoxic ribonuclease alpha-sarcin reveals the structural requirements for substrate recognition and ribonucleolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Insights into specificity of cleavage and mechanism of cell entry from the crystal structure of the highly specific Aspergillus ribotoxin, restrictocin

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Characterization of pKa values and titration shifts in the cytotoxic ribonuclease alpha-sarcin by NMR. Relationship between electrostatic interactions, structure, and catalytic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

A decade of protein engineering on ribonuclease T1--atomic dissection of the enzyme-substrate interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

A catalytic function for the structurally conserved residue Phe 100 of ribonuclease T1.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Probing the active site of mitogillin, a fungal ribotoxin

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Overproduction and purification of biologically active native fungal alpha-sarcin in Escherichia coli.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Substitution of histidine-137 by glutamine abolishes the catalytic activity of the ribosome-inactivating protein alpha-sarcin

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

21 January 2018

Protein stability curves

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Conformational stability of globular proteins

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Kinetic study of the aggregation and lipid mixing produced by alpha-sarcin on phosphatidylglycerol and phosphatidylserine vesicles: stopped-flow light scattering and fluorescence energy transfer measurements

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Use of resonance energy transfer to monitor membrane fusion

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Membrane interaction of a beta-structure-forming synthetic peptide comprising the 116-139th sequence region of the cytotoxic protein alpha-sarcin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Involvement of the amino-terminal beta-hairpin of the Aspergillus ribotoxins on the interaction with membranes and nonspecific ribonuclease activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

MOLMOL: a program for display and analysis of macromolecular structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Ribonuclease T1: Structure, Function, and Stability

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Reconsidering the energetics of ribonuclease catalysed RNA hydrolysis

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

A new method for determining the heat capacity change for protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Kinetic study of the cytotoxic effect of alpha-sarcin, a ribosome inactivating protein from Aspergillus giganteus, on tumour cell lines: protein biosynthesis inhibition and cell binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Oligomerization of the cytotoxin α-sarcin associated with phospholipid membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Hirsutellin A Displays Significant Homology to Microbial Extracellular Ribonucleases

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Complete amino acid sequence of the Aspergillus cytotoxin mitogillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

The cytotoxin α-sarcin behaves as a cyclizing ribonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Role of histidine-50, glutamic acid-96, and histidine-137 in the ribonucleolytic mechanism of the ribotoxin ?-sarcin

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Structural basis for the catalytic mechanism and substrate specificity of the ribonuclease α-sarcin

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Increase of solubility of foreign proteins in Escherichia coli by coproduction of the bacterial thioredoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

The solubility of the ribotoxin alpha-sarcin, produced as a recombinant protein in Escherichia coli, is increased in the presence of thioredoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Conformational study of the antitumor protein α-sarcin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Activity staining of nucleolytic enzymes after sodium dodecyl sulfate-polyacrylamide gel electrophoresis: Use of aqueous isopropanol to remove detergent from gels

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

A peptide of nine amino acid residues from alpha-sarcin cytotoxin is a membrane-perturbing structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

Assignment of the contribution of the tryptophan residues to the spectroscopic and functional properties of the ribotoxin alpha-sarcin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0014-2956.2001.02566.X

10.1046/J.0014-2956.2001.02566.X

21 January 2018

Identifiers

DOI

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27 November 2017

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