Metformin directly inhibits androgen production in human thecal cells (Q43726054)

26 November 2017

Metformin directly inhibits androgen production in human thecal cells (English)

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26 November 2017

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G R Attia

1

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26 November 2017

W E Rainey

series ordinal

2

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26 November 2017

B R Carr

series ordinal

3

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26 November 2017

language of work or name

English

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publication date

1 September 2001

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26 November 2017

Fertility and Sterility

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26 November 2017

76

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26 November 2017

3

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26 November 2017

517-524

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Polycystic ovary syndrome: interaction of follicle stimulating hormone and polypeptide growth factors in oestradiol production by human granulosa cells

26 November 2017

1 reference

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Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies

7 January 2021

1 reference

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Polycystic ovary syndrome

7 January 2021

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The diagnosis of polycystic ovaries in women with oligo-amenorrhoea: predictive power of endocrine tests

7 January 2021

1 reference

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Heterogeneity of the polycystic ovary syndrome: clinical, endocrine and ultrasound features in 556 patients

7 January 2021

1 reference

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Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus

7 January 2021

1 reference

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Selective insulin resistance in the polycystic ovary syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome

7 January 2021

1 reference

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Acanthosis nigricans and obesity: acquired and intrinsic defects in insulin action.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Insulin resistance with acanthosis nigricans: the roles of obesity and androgen excess

7 January 2021

1 reference

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Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome

7 January 2021

1 reference

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Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Menstrual cyclicity after metformin therapy in polycystic ovary syndrome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Polycystic ovary syndrome and risk for myocardial infarction. Evaluated from a risk factor model based on a prospective population study of women

7 January 2021

1 reference

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Obesity, lipids, cardiovascular risk, and androgen excess

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome

7 January 2021

1 reference

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Molecular and cellular aspects of the insulin-like growth factor I receptor

7 January 2021

1 reference

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7 January 2021

1 reference

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7 January 2021

1 reference

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Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

The effect of transforming growth factor-beta on steroidogenesis and expression of key steroidogenic enzymes with a human ovarian thecal-like tumor cell model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Inhibin and activin differentially regulate androgen production and 17 alpha-hydroxylase expression in human ovarian thecal-like tumor cells

7 January 2021

1 reference

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Insulin actions on ovarian steroidogenesis are not modulated by metformin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Regulation of cholesterol side-chain cleavage and 17 alpha-hydroxylase/lyase activities in proliferating human theca interna cells in long term monolayer culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Differential activity of the cytochrome P450 17alpha-hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

Metformin treatment reduces ovarian cytochrome P-450c17alpha response to human chorionic gonadotrophin in women with insulin resistance-related polycystic ovary syndrome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2801%2901975-6

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0015-0282(01)01975-6

1 reference

26 November 2017

1 reference