Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells (Q43723448)

26 November 2017

Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells (English)

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26 November 2017

Donovan JC

1

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26 November 2017

Milic A

series ordinal

2

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26 November 2017

Slingerland JM

series ordinal

3

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26 November 2017

language of work or name

English

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publication date

29 August 2001

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Journal of Biological Chemistry

26 November 2017

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26 November 2017

276

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26 November 2017

40888-40895

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26 November 2017

44

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CDK inhibitors: positive and negative regulators of G1-phase progression

26 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Translational control of p27Kip1 accumulation during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Cyclin E-CDK2 is a regulator of p27Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

p27 modulates cell cycle progression and chemosensitivity in human malignant glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Mitogen-activated protein kinase cascade in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Overexpression of c-erbB2 is an independent marker of resistance to endocrine therapy in advanced breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Third annual William L. McGuire Memorial Lecture. "Studies on the estrogen receptor in breast cancer"--20 years as a target for the treatment and prevention of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Oestrogen receptor: a stable phenotype in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Estrogen receptor mutations in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Acquired tamoxifen resistance: correlation with reduced breast tumor levels of tamoxifen and isomerization of trans-4-hydroxytamoxifen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Tamoxifen resistant breast cancer: coregulators determine the direction of transcription by antagonist-occupied steroid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

A human cell line from a pleural effusion derived from a breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY 117018.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

A pure estrogen antagonist inhibits cyclin E-Cdk2 activity in MCF-7 breast cancer cells and induces accumulation of p130-E2F4 complexes characteristic of quiescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

New functional activities for the p21 family of CDK inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Overexpression of mitogen-activated protein kinase superfamily proteins unrelated to Ras and AF-1 of estrogen receptor alpha mutation in advanced stage human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Epidermal growth factor receptor (EGFr) as a marker for poor prognosis in node-negative breast cancer patients: Neu and tamoxifen failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

ERBB2 amplification is associated with tamoxifen resistance in steroid-receptor positive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Expression of epidermal growth factor receptors associated with lack of response to endocrine therapy in recurrent breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

Potential prognostic value of mitogen-activated protein kinase activity for disease-free survival of primary breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106448200

21 January 2018

Identifiers

DOI

10.1074/JBC.M106448200

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26 November 2017

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