Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site (Q43704238)

26 November 2017

Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site (English)

1 reference

26 November 2017

1 reference

1 reference

Whittaker J

1

1 reference

26 November 2017

Groth AV

2

1 reference

26 November 2017

Mynarcik DC

3

1 reference

26 November 2017

Pluzek L

4

1 reference

26 November 2017

Gadsbøll VL

5

1 reference

26 November 2017

Whittaker LJ

6

1 reference

26 November 2017

language of work or name

English

0 references

publication date

10 August 2001

1 reference

Journal of Biological Chemistry

26 November 2017

1 reference

26 November 2017

276

1 reference

26 November 2017

47

1 reference

26 November 2017

43980-43986

1 reference

Role of insulin-like growth factors in embryonic and postnatal growth

26 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

The role of the insulin-like growth factor I receptor in transformation and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Structure and function of the type 1 insulin-like growth factor receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Crystal structure of the tyrosine kinase domain of the human insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

The insulin receptor: from protein sequence to structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Binding properties of chimeric insulin receptors containing the cysteine-rich domain of either the insulin-like growth factor I receptor or the insulin receptor related receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors. Insights into mechanisms of ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Receptor-binding region of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Mechanism of transmembrane signaling: insulin binding and the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Total alanine-scanning mutagenesis of insulin-like growth factor I (IGF-I) identifies differential binding epitopes for IGFBP-1 and IGFBP-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Structural changes in insulin-like growth factor (IGF) I mutant proteins affecting binding kinetic rates to IGF binding protein 1 and IGF-I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Mutations at Positions 11 and 60 of Insulin‐Like Growth Factor 1 Reveal Differences between its Interactions with the Type I Insulin‐Like‐Growth‐Factor Receptor and the Insulin Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Receptor binding redefined by a structural switch in a mutant human insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Importance of receptor occupancy, concentration differences, and ligand exchange in the insulin-like growth factor I receptor system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

The insulin-like growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Members of the insulin receptor family contain three fibronectin type III domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Specificity of insulin and insulin-like growth factor I receptors investigated using chimeric mini-receptors. Role of C-terminal of receptor alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Structural domains of the insulin receptor and IGF receptor required for dimerisation and ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Alanine-scanning mutagenesis of a C-terminal ligand binding domain of the insulin receptor alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Analog binding properties of insulin receptor mutants. Identification of amino acids interacting with the COOH terminus of the B-chain of the insulin molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Characterization of the three 125I-iodination isomers of human insulin-like growth factor I (IGF1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

18 Systematic mutational analyses of protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Alanine scanning mutagenesis of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Involvement of phenylalanine 23 in the binding of IGF-1 to the insulin and type I IGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

A model for insulin binding to the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102863200

21 January 2018

Identifiers

DOI

10.1074/JBC.M102863200

1 reference

26 November 2017

1 reference