The selectivity filter of the voltage-gated sodium channel is involved in channel activation (Q43624026)

25 November 2017

The selectivity filter of the voltage-gated sodium channel is involved in channel activation (English)

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25 November 2017

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9

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25 November 2017

Hilber K

1

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25 November 2017

Sandtner W

2

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25 November 2017

Kudlacek O

3

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25 November 2017

Glaaser IW

4

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25 November 2017

Weisz E

5

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25 November 2017

Kyle JW

6

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25 November 2017

French RJ

7

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25 November 2017

Fozzard HA

8

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25 November 2017

Todt H

10

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25 November 2017

language of work or name

English

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publication date

29 May 2001

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Journal of Biological Chemistry

25 November 2017

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25 November 2017

276

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25 November 2017

30

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25 November 2017

27831-27839

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Coupling between fast and slow inactivation revealed by analysis of a point mutation (F1304Q) in mu 1 rat skeletal muscle sodium channels

25 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat micro1 skeletal muscle sodium channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Impaired slow inactivation in mutant sodium channels

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M101933200

Slow inactivation of muscle mu1 Na+ channels in permanently transfected mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M101933200

Interaction between fast and slow inactivation in Skm1 sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Comparison between slow sodium channel inactivation in rat slow- and fast-twitch muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Ion-channel defects and aberrant excitability in myotonia and periodic paralysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Lidocaine action on Na+ currents in ventricular myocytes from the epicardial border zone of the infarcted heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Control of ion flux and selectivity by negatively charged residues in the outer mouth of rat sodium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Structure of the sodium channel pore revealed by serial cysteine mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M101933200

Immobilizing the moving parts of voltage-gated ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Role of domain 4 in sodium channel slow inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Pore-blocking toxins as probes of voltage-dependent channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Functional association of the beta 1 subunit with human cardiac (hH1) and rat skeletal muscle (mu 1) sodium channel alpha subunits expressed in Xenopus oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Modal behavior of the mu 1 Na+ channel and effects of coexpression of the beta 1-subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Inactivation of Ca channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Multiple gating modes and the effect of modulating factors on the μI sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Modification of the Na+ current conducted by the rat skeletal muscle alpha subunit by coexpression with a human brain beta subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

μl Na+ channels expressed transiently in human embryonic kidney cells: Biochemical and biophysical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Calcium channel characteristics conferred on the sodium channel by single mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Inactivation of batrachotoxin-modified Na+ channels in GH3 cells. Characterization and pharmacological modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Functional availability of sodium channels modulated by cytosolic free Ca2+ in cultured mammalian neurons (N1E-115).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Inactivation of Kv2.1 potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Preferential closed-state inactivation of neuronal calcium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

N-type calcium channel inactivation probed by gating-current analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Inactivation of delayed outward current in molluscan neurone somata

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Properties of somatic membrane patches of snail neurons under voltage clamp

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

State-dependent inactivation of K+ currents in rat type II alveolar epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

A Shab potassium channel contributes to action potential broadening in peptidergic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Accumulation of long-lasting inactivation in rat brain K(+)-channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Fast inactivation of delayed rectifier K conductance in squid giant axon and its cell bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Inactivation of voltage-gated delayed potassium current in molluscan neurons. A kinetic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Molecular motions within the pore of voltage-dependent sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

P-loop flexibility in Na+ channel pores revealed by single- and double-cysteine replacements

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Functional expression of sodium channel mutations identified in families with periodic paralysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

A mutation in segment IVS6 disrupts fast inactivation of sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Slow inactivation differs among mutant Na channels associated with myotonia and periodic paralysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Batrachotoxin as a tool to study voltage-sensitive sodium channels of excitable membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Sodium channel selectivity filter regulates antiarrhythmic drug binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Isoform-specific lidocaine block of sodium channels explained by differences in gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Lidocaine alters activation gating of cardiac Na channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Post-repolarization block of cardiac sodium channels by saxitoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Structural rearrangements underlying K+-channel activation gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Cardiac sodium channels (hH1) are intrinsically more sensitive to block by lidocaine than are skeletal muscle (mu 1) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

Structural parts involved in activation and inactivation of the sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101933200

21 January 2018

Identifiers

DOI

10.1074/JBC.M101933200

1 reference

25 November 2017

1 reference