A pivotal role of cysteine 3 of Lck tyrosine kinase for localization to glycolipid-enriched microdomains and T cell activation. (Q43557044)

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5 November 2019

title

A pivotal role of cysteine 3 of Lck tyrosine kinase for localization to glycolipid-enriched microdomains and T cell activation (English)

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5 November 2019

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4

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5 November 2019

author name string

A Kosugi

1

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5 November 2019

F Hayashi

2

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5 November 2019

D R Liddicoat

3

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5 November 2019

S Saitoh

5

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5 November 2019

T Hamaoka

6

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5 November 2019

publication date

1 March 2001

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5 November 2019

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5 November 2019

volume

76

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5 November 2019

issue

2

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5 November 2019

page(s)

133-138

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Signal transduction by lymphocyte antigen receptors

5 November 2019

cites work

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Myristylation and palmitylation of Src family members: the fats of the matter

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Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

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Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction

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Functional rafts in cell membranes

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Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains

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Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae

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7 January 2021

Amino-terminal palmitate or polybasic domain can provide required second signal to myristate for membrane binding of p56lck

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7 January 2021

Palmitoylation of either Cys-3 or Cys-5 is required for the biological activity of the Lck tyrosine protein kinase

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Intrinsic signals in the unique domain target p56(lck) to the plasma membrane independently of CD4.

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S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes

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A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

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7 January 2021

Translocation of tyrosine-phosphorylated TCRzeta chain to glycolipid-enriched membrane domains upon T cell activation

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7 January 2021

Accumulation of p60lck in HTLV-I-transformed T cell lines detected by an anti-lck monoclonal antibody, MOL 171.

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7 January 2021

Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins

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7 January 2021

Membrane compartmentation is required for efficient T cell activation.

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7 January 2021

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

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7 January 2021

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

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7 January 2021

T lymphocyte costimulation mediated by reorganization of membrane microdomains

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7 January 2021

Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor

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7 January 2021

10.1016/S0165-2478(01)00174-2

Identifiers

DOI

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5 November 2019

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