BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution (Q43284919)

18 November 2017

title

BAG1 modulates huntingtin toxicity, aggregation, degradation, and subcellular distribution (English)

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18 November 2017

5

Jörg B Schulz

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18 November 2017

Kamila Sroka

1

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18 November 2017

Aaron Voigt

2

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18 November 2017

Sebastian Deeg

3

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18 November 2017

John C Reed

4

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18 November 2017

Mathias Bähr

6

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18 November 2017

Pawel Kermer

7

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18 November 2017

language of work or name

English

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publication date

27 August 2009

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Journal of Neurochemistry

18 November 2017

published in

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18 November 2017

volume

111

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18 November 2017

issue

3

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18 November 2017

page(s)

801-807

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CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation

18 November 2017

cites work

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH

21 January 2018

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Global changes to the ubiquitin system in Huntington's disease.

21 January 2018

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Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

21 January 2018

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Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

21 January 2018

1 reference

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Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 January 2018

1 reference

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Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

21 January 2018

1 reference

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S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

21 January 2018

1 reference

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GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1

21 January 2018

1 reference

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

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BAG-1 associates with the polyglutamine-expanded huntingtin aggregates.

21 January 2018

1 reference

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

1 reference

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

1 reference

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Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

21 January 2018

1 reference

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Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice

21 January 2018

1 reference

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Nuclear targeting of mutant Huntingtin increases toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

BAG-1 modulates the chaperone activity of Hsp70/Hsc70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2009.06363.X

10.1111/J.1471-4159.2009.06363.X

21 January 2018

Identifiers

DOI

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18 November 2017

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