Critical signaling pathways in bone sarcoma: candidates for therapeutic interventions (Q43258817)

17 November 2017

Critical signaling pathways in bone sarcoma: candidates for therapeutic interventions (English)

1 reference

17 November 2017

Mandy Geryk-Hall

1

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PubMed ID

19840522

17 November 2017

Dennis P M Hughes

series ordinal

2

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17 November 2017

1 November 2009

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17 November 2017

Current Oncology Reports

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17 November 2017

11

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17 November 2017

446-453

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17 November 2017

6

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https://scigraph.springernature.com/pub.10.1007/s11912-009-0061-z

17 November 2017

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Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy

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Suppression of Ewing's sarcoma tumor growth, tumor vessel formation, and vasculogenesis following anti vascular endothelial growth factor receptor-2 therapy

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Wnt/Frizzled signaling in Ewing sarcoma

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Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcoma

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Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabine

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E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase

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Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth

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Inhibition of Src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo

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Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools

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Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma

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Critical role of notch signaling in osteosarcoma invasion and metastasis

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Inactivation of the RASSF1A in osteosarcoma

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12 December 2020

mTOR inhibitors (rapamycin and its derivatives) and nitrogen containing bisphosphonates: bi-functional compounds for the treatment of bone tumours

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Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma

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Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies

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Targeting ErbB receptor signaling: a pan-ErbB approach to cancer

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Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines.

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Emerging pathways in the development of chondrosarcoma of bone and implications for targeted treatment

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Zoledronic acid activates the DNA S-phase checkpoint and induces osteosarcoma cell death characterized by apoptosis-inducing factor and endonuclease-G translocation independently of p53 and retinoblastoma status

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Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors

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Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma

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Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton

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12 December 2020

Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma

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Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma

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Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma.

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Epidermal growth factor receptor in osteosarcoma: expression and mutational analysis

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The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts

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Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family

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12 December 2020

Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival

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12 December 2020

Notch signaling, gamma-secretase inhibitors, and cancer therapy

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12 December 2020

The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC.

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12 December 2020

Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

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12 December 2020

Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro

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12 December 2020

The biology behind mTOR inhibition in sarcoma

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12 December 2020

Fas expression in lung metastasis from osteosarcoma patients

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12 December 2020

Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program

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12 December 2020

Stromal cell-derived factor-1 stimulates vasculogenesis and enhances Ewing's sarcoma tumor growth in the absence of vascular endothelial growth factor

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Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway

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Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.

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Notch signaling contributes to the pathogenesis of human osteosarcomas

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Regulation of beta-catenin signaling in the Wnt pathway

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Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts

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A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies

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12 December 2020

The role of IGF-1R in pediatric malignancies

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12 December 2020

Biology and therapeutic advances for pediatric osteosarcoma

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12 December 2020

Oncogene alterations in primary, recurrent, and metastatic human bone tumors

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12 December 2020

Adjuvant and neoadjuvant combination chemotherapy for osteogenic sarcoma

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12 December 2020

10.1007/S11912-009-0061-Z

Identifiers

DOI

1 reference

release_w775svei7ff23hxvfp5ggcsjpy

17 November 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/w775svei7ff23hxvfp5ggcsjpy

24 November 2022

mapped directly with Wikidata item

PubMed ID

19840522

1 reference

PubMed ID

19840522