Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis (Q43234873)

16 November 2017

Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis (English)

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16 November 2017

4

Cristina Nevado

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16 November 2017

5

Amedeo Caflisch

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16 November 2017

Danzhi Huang

1

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16 November 2017

Ting Zhou

series ordinal

2

1 reference

16 November 2017

Karine Lafleur

series ordinal

3

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16 November 2017

language of work or name

English

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publication date

26 November 2009

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16 November 2017

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16 November 2017

26

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16 November 2017

198-204

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16 November 2017

2

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The selectivity of protein kinase inhibitors: a further update

16 November 2017

1 reference

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Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.

21 January 2018

1 reference

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Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines

21 January 2018

1 reference

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The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Kinase domain mutations in cancer: implications for small molecule drug design strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation

21 January 2018

1 reference

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Structure-guided development of affinity probes for tyrosine kinases using chemical genetics

21 January 2018

1 reference

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Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors

21 January 2018

1 reference

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A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding

21 January 2018

1 reference

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Molecular basis for specificity in the druggable kinome: sequence-based analysis

21 January 2018

1 reference

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Structural clues to prion replication

21 January 2018

1 reference

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Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

1 reference

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Specific targeted therapy of chronic myelogenous leukemia with imatinib

21 January 2018

1 reference

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Switching on kinases: oncogenic activation of BRAF and the PDGFR family

21 January 2018

1 reference

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Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

21 January 2018

1 reference

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A small molecule-kinase interaction map for clinical kinase inhibitors

21 January 2018

1 reference

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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

21 January 2018

1 reference

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Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

21 January 2018

1 reference

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Graph drawing by force-directed placement

21 January 2018

1 reference

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Comprehensive assessment of automatic structural alignment against a manual standard, the scop classification of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Substrate and docking interactions in serine/threonine protein kinases

21 January 2018

1 reference

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High-throughput kinase profiling as a platform for drug discovery

21 January 2018

1 reference

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

1 reference

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Amino acid substitution matrices from protein blocks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Network pharmacology: the next paradigm in drug discovery

21 January 2018

1 reference

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The structure of dimeric ROCK I reveals the mechanism for ligand selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

A quantitative analysis of kinase inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Features of selective kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Structure-based tailoring of compound libraries for high-throughput screening: discovery of novel EphB4 kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Rational design of inhibitors that bind to inactive kinase conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Protein kinase inhibitors: insights into drug design from structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

21 January 2018

Targeted cancer therapy

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

21 January 2018

1 reference

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High affinity targets of protein kinase inhibitors have similar residues at the positions energetically important for binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions

21 January 2018

1 reference

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Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Strategies toward the design of novel and selective protein tyrosine kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Kinomics-structural biology and chemogenomics of kinase inhibitors and targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Kinomics: characterizing the therapeutically validated kinase space.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Sequence and structural analysis of kinase ATP pocket residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

The clinical implications of sunitinib-induced hypothyroidism: a prospective evaluation

21 January 2018

1 reference

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A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

21 January 2018

1 reference

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Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBIOINFORMATICS%2FBTP650

10.1093/BIOINFORMATICS/BTP650

21 January 2018

Identifiers

DOI

1 reference

journals/bioinformatics/HuangZLNC10

16 November 2017

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference