PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production (Q43220263)

16 November 2017

PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production (English)

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16 November 2017

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I P Lewkowich

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S Lajoie

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S L Stoffers

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Y Suzuki

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P K Richgels

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K Dienger

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A A Sproles

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H Yagita

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Q Hamid

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M Wills-Karp

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14 November 2012

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728-739

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https://scigraph.springernature.com/pub.10.1038/mi.2012.111

16 November 2017

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Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness.

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Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation

25 May 2018

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Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice

25 May 2018

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Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

25 May 2018

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Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

25 May 2018

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Programmed Death-1 antibody blocks therapeutic effects of T-regulatory cells in cockroach antigen-induced allergic asthma

25 May 2018

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PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions

25 May 2018

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Programmed death-1 receptor negatively regulates LPS-mediated IL-12 production and differentiation of murine macrophage RAW264.7 cells

25 May 2018

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25 May 2018

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Inhibition of acidic mammalian chitinase by RNA interference suppresses ovalbumin-sensitized allergic asthma

25 May 2018

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PD-1 on dendritic cells impedes innate immunity against bacterial infection

25 May 2018

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Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice

25 May 2018

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Increased expression of ADAM33 and ADAM8 with disease progression in asthma

25 May 2018

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25 May 2018

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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

25 May 2018

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Tissue expression of PD-L1 mediates peripheral T cell tolerance.

25 May 2018

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No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation

25 May 2018

1 reference

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Restoring function in exhausted CD8 T cells during chronic viral infection

25 May 2018

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Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production

25 May 2018

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In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses

25 May 2018

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Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells

25 May 2018

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Preferential contribution of B7‐H1 to programmed death‐1‐mediated regulation of hapten‐specific allergic inflammatory responses

25 May 2018

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Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor

25 May 2018

1 reference

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Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction

25 May 2018

1 reference

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Expression of programmed death 1 ligands by murine T cells and APC

25 May 2018

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Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

25 May 2018

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

25 May 2018

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Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation

25 May 2018

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B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells

25 May 2018

1 reference

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

25 May 2018

1 reference

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

25 May 2018

1 reference

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Sensitization to inhaled antigen by intratracheal instillation of dendritic cells.

25 May 2018

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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

25 May 2018

1 reference

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Interleukin-13: central mediator of allergic asthma

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death

25 May 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

25 May 2018

https://api.crossref.org/works/10.1038%2FMI.2012.111

7 January 2021

inferred from DOI database lookup

An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Suppressive effect of IL-4 on IL-13-induced genes in mouse lung.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Interleukin-13 in asthma pathogenesis.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

In vivo IgE levels in exogenous antigen stimulated responses: measurement of total IgE as a valid, simple surrogate for Ag-specific IgE.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Programmed death-1 targeting can promote allograft survival

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Involvement of the mannose receptor in the uptake of Der p 1, a major mite allergen, by human dendritic cells.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Failure of rIL-12 administration to inhibit established IgE responses in vivo is associated with enhanced IL-4 synthesis by non-B/non-T cells.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Resistance to antigen-induced airway hyperresponsiveness requires endogenous production of IL-12.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3605233

Acidic mammalian chitinase is not a critical target for allergic airway disease

3 November 2018

1 reference

12 December 2020

Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society

1 reference

12 December 2020

Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma

1 reference

12 December 2020

Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice

1 reference

12 December 2020

Development of murine allergic asthma is dependent upon B7-2 costimulation

1 reference

12 December 2020

Paradoxical role of programmed death-1 ligand 2 in Th2 immune responses in vitro and in a mouse asthma model in vivo

1 reference

12 December 2020

The Pro-Th1 cytokine IL-12 enhances IL-4 production by invariant NKT cells: relevance for T cell-mediated hepatitis

1 reference

12 December 2020

B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma

1 reference

12 December 2020

Identifiers

DOI

10.1038/MI.2012.111

1 reference

16 November 2017

1 reference

16 November 2017

1 reference