Synthetic studies of complex immunostimulants from Quillaja saponaria: synthesis of the potent clinical immunoadjuvant QS-21Aapi. (Q43211393)

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29 December 2019

title

Synthetic studies of complex immunostimulants from Quillaja saponaria: synthesis of the potent clinical immunoadjuvant QS-21Aapi (English)

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29 December 2019

Quillaja saponaria

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Mauricio Navarro-Villalobos

inferred from title

author

3

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29 December 2019

author name string

Yong-Jae Kim

1

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29 December 2019

Pengfei Wang

2

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29 December 2019

Bridget D Rohde

4

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JohnMark Derryberry

5

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David Y Gin

6

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language of work or name

English

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publication date

1 September 2006

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Journal of the American Chemical Society

29 December 2019

published in

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volume

128

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issue

36

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page(s)

11906-11915

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Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial

29 December 2019

cites work

1 reference

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Effect of immunological adjuvant combinations on the antibody and T-cell response to vaccination with MUC1-KLH and GD3-KLH conjugates.

25 May 2018

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Uptake and adjuvant activity of orally delivered saponin and ISCOM vaccines

25 May 2018

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Carbohydrate vaccines in cancer: immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man.

25 May 2018

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ISCOMs (immunostimulating complexes): the first decade

25 May 2018

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Saponins as vaccine adjuvants

25 May 2018

1 reference

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Saponin adjuvants. 3. Isolation of a substance from Quillaja saponaria Molina with adjuvant activity in food-and-mouth disease vaccines.

25 May 2018

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Total synthesis of polycavernoside A, a lethal toxin of the red alga Polycavernosa tsudai

25 May 2018

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Synthesis of the potent immunostimulatory adjuvant QS-21A.

15 August 2018

1 reference

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Potent, long lasting systemic antibody levels and mixed Th1/Th2 immune response after nasal immunization with malaria antigen loaded PLGA microparticles.

15 August 2018

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Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin.

15 August 2018

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C2-hydroxyglycosylation with glycal donors. Probing the mechanism of sulfonium-mediated oxygen transfer to glycal enol ethers

15 August 2018

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Studies on the synthesis of landomycin A: synthesis and glycosidation reactions of L-rhodinosyl acetate derivatives

15 August 2018

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C2-acyloxyglycosylation with glycal donors

15 August 2018

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QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immmunization in humans

15 August 2018

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12 December 2020

Synthesis of the trisaccharide portion of the immunologic adjuvant QS-21A via sulfonium-mediated oxidative and dehydrative glycosylation

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12 December 2020

Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21

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12 December 2020

Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex

1 reference

12 December 2020

Chiral synthesis via organoboranes. 7. Diastereoselective and enantioselective synthesis of erythro- and threo-.beta.-methylhomoallyl alcohols via enantiomeric (Z)- and (E)-crotylboranes

1 reference

12 December 2020

Chemoselective Iterative Dehydrative Glycosylation

1 reference

12 December 2020

Anomeric-oxygen activation for glycoside synthesis: the trichloroacetimidate method

1 reference

12 December 2020

Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy

1 reference

12 December 2020

Isomerization and formulation stability of the vaccine adjuvant QS-21

1 reference

12 December 2020

Induction of cross-reactive cytotoxic T-lymphocyte responses specific for HIV-1 gp120 using saponin adjuvant (QS-21) supplemented subunit vaccine formulations

1 reference

12 December 2020

Identifiers

DOI

10.1021/JA062364I

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29 December 2019

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