Inhibition of GTPase activity of Gi proteins and decreased agonist affinity at M2 muscarinic acetylcholine receptors by spermine and methoctramine. (Q43193572)

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scientific article published in June 1999

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English	Inhibition of GTPase activity of Gi proteins and decreased agonist affinity at M2 muscarinic acetylcholine receptors by spermine and methoctramine.	scientific article published in June 1999

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scholarly article

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10 December 2019

Inhibition of GTPase activity of Gi proteins and decreased agonist affinity at M2 muscarinic acetylcholine receptors by spermine and methoctramine (English)

1 reference

Europe PubMed Central

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10 December 2019

Laurent Daeffler

1

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10 December 2019

author name string

A Chahdi

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10 December 2019

J P Gies

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10 December 2019

Y Landry

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10 December 2019

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1 June 1999

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10 December 2019

British Journal of Pharmacology

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10 December 2019

127

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10 December 2019

4

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10 December 2019

1021-1029

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10 December 2019

Inverse agonist activity of pirenzepine at M2 muscarinic acetylcholine receptors.

1 reference

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25 May 2018

Melittin, a metabostatic peptide inhibiting Gs activity.

1 reference

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Drugs interacting with G protein alpha subunits: selectivity and perspectives

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25 May 2018

G protein beta gamma subunits.

1 reference

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25 May 2018

Modulation of channel function by polyamines

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Aminoglycosides and polyamines: targets and effects in the mammalian organism of two important groups of natural aliphatic polycations.

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Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors

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25 May 2018

Interactions of polyamines with neuronal ion channels

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25 May 2018

The two-state model of receptor activation

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25 May 2018

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Log-normal distribution of equiefective doses of norepinephrine and acetylcholine in several tissues.

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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Differential blockade of muscarinic receptor subtypes by polymethylene tetraamines. Novel class of selective antagonists of cardiac M-2 muscarinic receptors

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25 May 2018

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

1 reference

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25 May 2018

G proteins: transducers of receptor-generated signals

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25 May 2018

Influence of polyamines on membrane functions

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Essential synergy between Ca2+ and guanine nucleotides in exocytotic secretion from permeabilized rat mast cells

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25 May 2018

Effect of bacterial toxins on spermine-induced inhibition of adenylate cyclase activity of cultured heart cells.

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G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides.

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25 May 2018

Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.

1 reference

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25 May 2018

Inhibition of adenylate cyclase activity by polyamines in human erythrocyte plasma membranes

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25 May 2018

Pharmacological properties of the natural polyamines and their depletion by biosynthesis inhibitors as a therapeutic approach

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25 May 2018

Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells

1 reference

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25 May 2018

G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding

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25 May 2018

Natural polyamines stimulate G-proteins

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The binding of antagonists to brain muscarinic receptors

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25 May 2018

The binding of agonists to brain muscarinic receptors

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25 May 2018

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

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Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

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The M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins.

1 reference

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Mapping of the mastoparan-binding site on G proteins. Cross-linking of [125I-Tyr3,Cys11]mastoparan to Go.

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12 December 2020

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Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10433511

12 December 2020

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Large scale preparation and characterization of membrane-bound and detergent-solubilized muscarinic acetylcholine receptor from pig atria

1 reference

https://pubmed.ncbi.nlm.nih.gov/10433511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADP-ribosylation of Gs promotes the dissociation of its alpha and beta subunits

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spermine inhibition of basal and stimulated adenylate cyclase is mediated by the inhibitory GTP-binding protein (Gi)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10433511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cardiac G-proteins by muscarinic acetylcholine receptors: regulation by Mg2+ and Na+ ions

1 reference

https://pubmed.ncbi.nlm.nih.gov/10433511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methoctramine, a cardioselective muscarinic antagonist, stimulates phosphoinositide hydrolysis in rat cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/10433511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct activation of GTP-binding regulatory proteins (G-proteins) by substance P and compound 48/80

1 reference

https://pubmed.ncbi.nlm.nih.gov/10433511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis for cellular effects of naturally occurring polyamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/10433511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist-independent inhibition of G protein activation by muscarinic acetylcholine receptor antagonists in cardiac membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10433511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of exocytosis by the heterotrimeric G protein Gi3

1 reference

https://pubmed.ncbi.nlm.nih.gov/10433511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substance P-related inhibitors of mast cell exocytosis act on G-proteins or on the cell surface

1 reference

https://pubmed.ncbi.nlm.nih.gov/10433511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0702625

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10433511%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10433511%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10433511%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

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