The isolated rabbit heart and Purkinje fibers as models for identifying proarrhythmic liability (Q43179699)

15 November 2017

The isolated rabbit heart and Purkinje fibers as models for identifying proarrhythmic liability (English)

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15 November 2017

Michel Roche

1

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15 November 2017

Céline Renauleaud

2

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15 November 2017

Véronique Ballet

3

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15 November 2017

Michel Doubovetzky

4

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15 November 2017

Jean-Michel Guillon

5

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15 November 2017

1 February 2010

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Journal of Pharmacological and Toxicological Methods

15 November 2017

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15 November 2017

61

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15 November 2017

3

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15 November 2017

238-250

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Dofetilide-induced long QT and torsades de pointes.

15 November 2017

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https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.01.011

The pharmacokinetics and pharmacodynamics of oral dofetilide after twice daily and three times daily dosing

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Arrhythmogenic mechanisms of QT prolonging drugs: is QT prolongation really the problem?

7 January 2021

1 reference

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Heterogeneity and cardiac arrhythmias: an overview.

7 January 2021

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Transmural dispersion of repolarization and arrhythmogenicity: the Brugada syndrome versus the long QT syndrome

7 January 2021

1 reference

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Evaluation of the rabbit Purkinje fibre assay as an in vitro tool for assessing the risk of drug-induced torsades de pointes in humans

7 January 2021

1 reference

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Assessing predictors of drug-induced torsade de pointes.

7 January 2021

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Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs

7 January 2021

1 reference

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Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts.

7 January 2021

1 reference

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Isolated perfused and paced guinea pig heart to test for drug-induced changes of the QT interval

7 January 2021

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Influence of dofetilide on QT-interval duration and dispersion at various heart rates during exercise in humans

7 January 2021

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The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns

7 January 2021

1 reference

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Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome: detailed analysis of ventricular tridimensional activation patterns

7 January 2021

1 reference

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Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing

7 January 2021

1 reference

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L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species

7 January 2021

1 reference

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Drug-induced torsades de pointes: role of early afterdepolarizations and dispersion of repolarization

7 January 2021

1 reference

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Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide

7 January 2021

1 reference

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What is a monophasic action potential?

7 January 2021

1 reference

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Cellular basis for the monophasic action potential. Which electrode is the recording electrode?

7 January 2021

1 reference

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A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

7 January 2021

1 reference

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Pharmacokinetic and pharmacodynamic modeling of the effects of oral and intravenous administrations of dofetilide on ventricular repolarization*

7 January 2021

1 reference

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Sex modulates the arrhythmogenic substrate in prepubertal rabbit hearts with Long QT 2.

7 January 2021

1 reference

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Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations

7 January 2021

1 reference

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Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes

7 January 2021

1 reference

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Principles of safety pharmacology

7 January 2021

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A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.

7 January 2021

1 reference

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Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2

7 January 2021

1 reference

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Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model

7 January 2021

1 reference

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Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group

7 January 2021

1 reference

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Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome

7 January 2021

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Ventricular repolarization components on the electrocardiogram: cellular basis and clinical significance

7 January 2021

1 reference

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Modulating effects of age and gender on the clinical course of long QT syndrome by genotype

7 January 2021

1 reference

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Detection of proarrhythmia in the female rabbit heart: blinded validation

7 January 2021

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.VASCN.2010.01.011

1 reference

15 November 2017

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