Influence of selective fluorination on the biological activity and proteolytic stability of glucagon-like peptide-1. (Q43177381)

15 November 2017

Influence of selective fluorination on the biological activity and proteolytic stability of glucagon-like peptide-1. (English)

1 reference

15 November 2017

1 reference

He Meng

1

1 reference

15 November 2017

Subrahmanian Tarakkad Krishnaji

series ordinal

2

1 reference

15 November 2017

Martin Beinborn

series ordinal

3

1 reference

15 November 2017

Krishna Kumar

series ordinal

4

1 reference

15 November 2017

language of work or name

English

0 references

publication date

1 November 2008

1 reference

Journal of Medicinal Chemistry

15 November 2017

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15 November 2017

51

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15 November 2017

22

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15 November 2017

7303-7307

1 reference

Fluorine in pharmaceuticals: looking beyond intuition

15 November 2017

1 reference

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Therapeutic peptides: technological advances driving peptides into development

25 May 2018

1 reference

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Epidemiologic and economic consequences of the global epidemics of obesity and diabetes

25 May 2018

1 reference

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A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness

25 May 2018

1 reference

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Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus

25 May 2018

1 reference

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Glucagon-like peptide-1: the basis of a new class of treatment for type 2 diabetes.

25 May 2018

1 reference

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Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production.

25 May 2018

1 reference

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Fluorine in medicinal chemistry

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645917

The polar hydrophobicity of fluorinated compounds.

25 May 2018

1 reference

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Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo.

25 May 2018

1 reference

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[Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo

25 May 2018

1 reference

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A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors.

25 May 2018

1 reference

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Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes

25 May 2018

1 reference

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Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration

25 May 2018

1 reference

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Dipeptidyl-peptidase IV (CD26)--role in the inactivation of regulatory peptides

25 May 2018

1 reference

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Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

25 May 2018

1 reference

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Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645917

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

25 May 2018

1 reference

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Structure-activity studies of glucagon-like peptide-1.

25 May 2018

1 reference

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Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication

25 May 2018

1 reference

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Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function

25 May 2018

1 reference

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Antimicrobial activity and protease stability of peptides containing fluorinated amino acids.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645917

Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice.

15 August 2018

1 reference

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(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645917

Fluorous effect in proteins: de novo design and characterization of a four-alpha-helix bundle protein containing hexafluoroleucine

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645917

Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39).

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645917

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645917

A small molecule ligand of the glucagon-like peptide 1 receptor targets its amino-terminal hormone binding domain

15 August 2018

1 reference

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Self-association and membrane-binding behavior of melittins containing trifluoroleucine

15 August 2018

1 reference

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Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2645917

Using Fluorous Amino Acids to Modulate the Biological Activity of an Antimicrobial Peptide

15 August 2018

1 reference

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Synthesis of fluorine-containing peptides. Analogs of angiotensin II containing hexafluorovaline

1 December 2018

1 reference

12 December 2020

Structure of glucagon-like peptide (7-36) amide in a dodecylphosphocholine micelle as determined by 2D NMR

1 reference

12 December 2020

Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy Subjects

1 reference

12 December 2020

The positive charge of the imidazole side chain of histidine7 is crucial for GLP-1 action

1 reference

12 December 2020

A synthetic glucagon-like peptide-1 analog with improved plasma stability

1 reference

12 December 2020

The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity

1 reference

12 December 2020

Synthesis, biological activity, and 19 F nuclear magnetic resonance spectra of angiotensin II analogs containing fluorine

1 reference

12 December 2020

Helix propensity of highly fluorinated amino acids

1 reference

12 December 2020

A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro

1 reference

12 December 2020

Long-acting angiotensin II inhibitors containing hexafluorovaline in position 8

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM8008579

1 reference

release_qyzh6kt4frb7vjyjr7nkzc3v7i

15 November 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qyzh6kt4frb7vjyjr7nkzc3v7i

24 November 2022

mapped directly with Wikidata item

1 reference

15 November 2017

PubMed publication ID

18950150

1 reference