Gamma-secretase inhibitors: Notch so bad. (Q43158031)

15 November 2017

Gamma-secretase inhibitors: Notch so bad. (English)

1 reference

15 November 2017

Gerard C Grosveld

1

1 reference

PMCID

2659646

15 November 2017

language of work or name

English

0 references

publication date

1 January 2009

1 reference

15 November 2017

1 reference

15 November 2017

15

1 reference

15 November 2017

1

1 reference

15 November 2017

20-21

1 reference

https://scigraph.springernature.com/pub.10.1038/nm0109-20

15 November 2017

0 references

cites work

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

Structure and function of gamma-secretase

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

Signaling pathways involved in the development of T-cell acute lymphoblastic leukemia

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2659646

Acute lymphoblastic leukaemia

15 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM0109-20

Emerging role of Notch in stem cells and cancer

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM0109-20

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NM0109-20

1 reference

15 November 2017

1 reference

15 November 2017

1 reference

PMCID

2659646