Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies. (Q43070206)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20065649%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies (English)

1 reference

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16 January 2020

1 reference

1 reference

2

1 reference

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16 January 2020

author name string

Xiaoling Wang

series ordinal

1

1 reference

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16 January 2020

Satish K Singh

series ordinal

3

1 reference

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16 January 2020

Sandeep Kumar

series ordinal

4

1 reference

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16 January 2020

publication date

29 May 2009

1 reference

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16 January 2020

published in

Monoclonal Antibodies

1 reference

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16 January 2020

volume

1

1 reference

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16 January 2020

page(s)

254-267

1 reference

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16 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20065649%20AND%20SRC:MED&resulttype=core&format=json

Atomistic simulations of the effects of polyglutamine chain length and solvent quality on conformational equilibria and spontaneous homodimerization

16 January 2020

cites work

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Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria

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Antibody therapeutics: isotype and glycoform selection

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25 May 2018

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Human immunoglobulin G2 (IgG2) and IgG4, but not IgG1 or IgG3, protect mice against Cryptococcus neoformans infection.

25 May 2018

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Generic hydrophobic residues are sufficient to promote aggregation of the Alzheimer's Abeta42 peptide

25 May 2018

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Effects of protein aggregates: an immunologic perspective

25 May 2018

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25 May 2018

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Latest technologies for the enhancement of antibody affinity

25 May 2018

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Protein misfolding, functional amyloid, and human disease

25 May 2018

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Potent antibody therapeutics by design

25 May 2018

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Assessing the role of aromatic residues in the amyloid aggregation of human muscle acylphosphatase

25 May 2018

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The yeast prion Ure2p native-like assemblies are toxic to mammalian cells regardless of their aggregation state.

25 May 2018

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25 May 2018

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Aspects on human amyloid forms and their fibril polypeptides

25 May 2018

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Prediction of "hot spots" of aggregation in disease-linked polypeptides

25 May 2018

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Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences

25 May 2018

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Characterization of a possible amyloidogenic precursor in glutamine-repeat neurodegenerative diseases

25 May 2018

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25 May 2018

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Structure of the cross-beta spine of amyloid-like fibrils

25 May 2018

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Protein aggregation and its inhibition in biopharmaceutics

25 May 2018

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Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

25 May 2018

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Structure-immunogenicity relationships of therapeutic proteins

25 May 2018

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Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

25 May 2018

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Conformational constraints for amyloid fibrillation: the importance of being unfolded

25 May 2018

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Challenges in the development of high protein concentration formulations

25 May 2018

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25 May 2018

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25 May 2018

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

25 May 2018

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Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril

25 May 2018

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Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

25 May 2018

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25 May 2018

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Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation

25 May 2018

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25 May 2018

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25 May 2018

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A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions

25 May 2018

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Review: history of the amyloid fibril

25 May 2018

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Glutamine repeats and neurodegeneration

25 May 2018

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Phage display: a molecular tool for the generation of antibodies--a review.

25 May 2018

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Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc

25 May 2018

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25 May 2018

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25 May 2018

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1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen

25 May 2018

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VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface

25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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25 May 2018

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The three-dimensional structure of an intact monoclonal antibody for canine lymphoma

25 May 2018

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25 May 2018

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25 May 2018

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15 August 2018

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15 August 2018

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15 August 2018

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15 August 2018

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15 August 2018

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15 August 2018

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15 August 2018

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15 August 2018

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Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

15 August 2018

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Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

15 August 2018

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Analysis of the minimal amyloid-forming fragment of the islet amyloid polypeptide. An experimental support for the key role of the phenylalanine residue in amyloid formation

15 August 2018

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Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv.

15 August 2018

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Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

15 August 2018

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Contrasting IgG Structures Reveal Extreme Asymmetry and Flexibility

15 August 2018

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A Role for Protein Misfolding in Immunogenicity of Biopharmaceuticals

21 January 2018

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Production of functional chimaeric mouse/human antibody

21 January 2018

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Antigen-specific human antibodies from mice comprising four distinct genetic modifications

21 January 2018

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Inter Heavy–Light Chain Disulphide Bridge in Immune Globulins

21 January 2018

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Monoclonal antibody therapy of cancer

21 January 2018

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12 December 2020

Amyloid fibrils formation and amorphous aggregation in concanavalin A

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Structural differences between the repertoires of mouse and human germline genes and their evolutionary implications

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Monoclonal antibody successes in the clinic

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12 December 2020

Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice

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Opalescent appearance of an IgG1 antibody at high concentrations and its relationship to noncovalent association

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Humanization of a mouse neutralizing monoclonal antibody against tumor necrosis factor-alpha (TNF-alpha)

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Identifiers

DOI

10.4161/MABS.1.3.8035

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20065649%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20065649%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference