Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection (Q43038296)

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scientific article published in June 2002

Language	Label	Description	Also known as
English	Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection	scientific article published in June 2002

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scholarly article

1 reference

Europe PubMed Central

12 November 2017

Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection (English)

1 reference

Europe PubMed Central

12 November 2017

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based on heuristic

inferred from title

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based on heuristic

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chronic hepatitis C

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based on heuristic

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chronic hepatitis

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author name string

Melissa D Murphy

1

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Europe PubMed Central

12 November 2017

Hugo R Rosen

2

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Europe PubMed Central

12 November 2017

Gail I Marousek

3

1 reference

Europe PubMed Central

12 November 2017

Sunwen Chou

4

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Europe PubMed Central

12 November 2017

publication date

1 June 2002

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Europe PubMed Central

12 November 2017

Digestive Diseases and Sciences

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Europe PubMed Central

12 November 2017

47

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Europe PubMed Central

12 November 2017

6

1 reference

Europe PubMed Central

12 November 2017

1195-1205

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Europe PubMed Central

12 November 2017

https://scigraph.springernature.com/pub.10.1023/a:1015349924116

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Efficacy and changes of the nonstructural 5A GENE by prolonged interferon therapy for patients with hepatitis C virus genotype 1b and a high level of serum HCV-RNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variation in the hepatitis C virus NS5a region in relation to hypervariable region 1 heterogeneity during interferon treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon plus ribavirin for chronic hepatitis C

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The epidemic behavior of the hepatitis C virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the NS5A region do not predict interferon-responsiveness in american patients infected with genotype 1b hepatitis C virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term response to interferon alpha is unrelated to "interferon sensitivity determining region" variability in patients with chronic hepatitis C virus-1b infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the NS5A gene predict response to interferon therapy in Japanese patients with chronic hepatitis C and cirrhosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the protein kinase-binding domain of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (I

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of amino acid sequence in the PKR-eIF2 phosphorylation homology domain and response to interferon therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prevalence of hepatitis C virus infection in the United States, 1988 through 1994

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response to retreatment with interferon-alpha plus ribavirin in chronic hepatitis C patients is independent of the NS5A gene nucleotide sequence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved correlation between multiple mutations within the NS5A region and virological response in European patients chronically infected with hepatitis C virus type 1b undergoing combination therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatitis C virus NS5A protein inhibits interferon antiviral activity, but the effects do not correlate with clinical response

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatitis C virus, the E2 envelope protein, and alpha-interferon resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amino acid sequence of the PKR-eIF2alpha phosphorylation homology domain of hepatitis C virus envelope 2 protein and response to interferon-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The "interferon sensitivity determining region" of hepatitis C virus is a stable sequence element

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease. Centers for Disease Control and Prevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Number and position of mutations in the interferon (IFN) sensitivity-determining region of the gene for nonstructural protein 5A correlate with IFN efficacy in hepatitis C virus genotype 1b infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management of hepatitis C

1 reference

https://pubmed.ncbi.nlm.nih.gov/12064791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1015349924116

1 reference

Europe PubMed Central

12 November 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

12 November 2017

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