Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy (Q43024864)

12 November 2017

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy (English)

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12 November 2017

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16

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1 June 2020

Jonathan J Keats

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1 June 2020

Mara Rosenberg

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Todd R Golub

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Ravid Straussman

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1 June 2020

3

Scott L Carter

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1 June 2020

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Carrie Sougnez

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1 June 2020

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Kristian Cibulskis

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Gad Getz

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Petar Stojanov

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18

Steven E Schumacher

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1 June 2020

9

Joshua Gould

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1 June 2020

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Gordon Saksena

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1 June 2020

6

Daniel Auclair

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1 June 2020

12

Aaron McKenna

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1 June 2020

1

Jens G Lohr

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1 June 2020

8

Birgit Knoechel

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1 June 2020

author name string

Peter Cruz-Gordillo

4

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1 June 2020

Michael S Lawrence

5

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1 June 2020

Michael A Chapman

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1 June 2020

Joan Levy

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1 June 2020

Multiple Myeloma Research Consortium

20

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1 June 2020

publication date

1 January 2014

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12 November 2017

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1 June 2020

volume

25

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1 June 2020

page(s)

91-101

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1 June 2020

issue

1

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Clonal evolution in hematological malignancies and therapeutic implications

1 June 2020

cites work

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Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Mutational heterogeneity in cancer and the search for new cancer-associated genes

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Targeting the BRAF V600E mutation in multiple myeloma

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

26 May 2018

1 reference

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Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

26 May 2018

1 reference

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Identification of unbalanced genome copy number abnormalities in patients with multiple myeloma by single-nucleotide polymorphism genotyping microarray analysis.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Addiction to c-MYC in multiple myeloma

26 May 2018

1 reference

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BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors

26 May 2018

1 reference

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The life history of 21 breast cancers

26 May 2018

1 reference

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Absolute quantification of somatic DNA alterations in human cancer

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Clonal competition with alternating dominance in multiple myeloma.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

26 May 2018

1 reference

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Clonal architecture of secondary acute myeloid leukemia

26 May 2018

1 reference

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

26 May 2018

1 reference

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Latest advances and current challenges in the treatment of multiple myeloma

26 May 2018

1 reference

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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

26 May 2018

1 reference

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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Integrated genomic analyses of ovarian carcinoma

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma

26 May 2018

1 reference

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GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

26 May 2018

1 reference

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Initial genome sequencing and analysis of multiple myeloma

26 May 2018

1 reference

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A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries

26 May 2018

1 reference

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A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

26 May 2018

1 reference

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26 May 2018

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

26 May 2018

1 reference

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Classical and/or alternative NF-kappaB pathway activation in multiple myeloma

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma

26 May 2018

1 reference

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International Myeloma Working Group molecular classification of multiple myeloma: spotlight review.

26 May 2018

1 reference

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Coexisting NRAS and BRAF mutations in primary familial melanomas with specific CDKN2A germline alterations

26 May 2018

1 reference

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Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing

26 May 2018

1 reference

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A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

26 May 2018

1 reference

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IRF4 addiction in multiple myeloma

26 May 2018

1 reference

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Induction of apoptosis in plasma cells by B lymphocyte-induced maturation protein-1 knockdown

26 May 2018

1 reference

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Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

26 May 2018

1 reference

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitor-resistant melanoma: a case illustrating the challenges for personalized medicine.

26 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Blimp1 is limiting for transformation in a mouse plasmacytoma model.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

Effect of tissue shipping on plasma cell isolation, viability, and RNA integrity in the context of a centralized good laboratory practice-certified tissue banking facility.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

16 August 2018

1 reference

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DNA Methylation Analysis Determines the High Frequency of Genic Hypomethylation and Low Frequency of Hypermethylation Events in Plasma Cell Tumors

30 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4241387

10.1016/J.CCR.2013.12.015

1 December 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24434212%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

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1 June 2020

1 reference

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