Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice. (Q42976899)

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7 February 2020

title

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice (English)

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7 February 2020

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7

Irene Knuesel

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7 February 2020

author name string

Samira Kocherhans

1

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7 February 2020

Amrita Madhusudan

2

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Jana Doehner

3

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7 February 2020

Karin S Breu

4

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Roger M Nitsch

5

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language of work or name

English

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publication date

1 July 2010

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7 February 2020

published in

Journal of Neuroscience

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volume

30

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7 February 2020

page(s)

9228-9240

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7 February 2020

issue

27

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describes a project that uses

7 February 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Reelin, the extracellular matrix protein deficient in reeler mutant mice, is processed by a metalloproteinase.

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation

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Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody

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Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

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The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

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Increased vulnerability to kainate-induced seizures in utrophin-knockout mice

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Secreted Reelin molecules form homodimers.

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Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

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Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta

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A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling

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Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade

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Genetic modulation of tau phosphorylation in the mouse.

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Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease.

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Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.

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The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

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Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

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Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin

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Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

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Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

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Reelin modulates NMDA receptor activity in cortical neurons.

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Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity

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Reelin expression and glycosylation patterns are altered in Alzheimer's disease

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Alzheimer's disease beta-amyloid peptides are released in association with exosomes

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Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice

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DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

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Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus.

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12 December 2020

Pathways by which Abeta facilitates tau pathology

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ApoE receptor 2 controls neuronal survival in the adult brain.

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Reelin signaling facilitates maturation of CA1 glutamatergic synapses

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Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

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Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.

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Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons.

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Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors

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12 December 2020

Regulated proteolysis of APP and ApoE receptors

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12 December 2020

Interaction of reelin with amyloid precursor protein promotes neurite outgrowth

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12 December 2020

Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging

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12 December 2020

Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease

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12 December 2020

Co-localization of Reelin and proteolytic AbetaPP fragments in hippocampal plaques in aged wild-type mice

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12 December 2020

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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10.1523/JNEUROSCI.0418-10.2010

Identifiers

DOI

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