Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase (Q42966864)

11 November 2017

Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase (English)

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11 November 2017

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9

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11 November 2017

Hans Henning von Horsten

1

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11 November 2017

Christiane Ogorek

2

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11 November 2017

Véronique Blanchard

3

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11 November 2017

Christian Demmler

4

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11 November 2017

Christoph Giese

5

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11 November 2017

Karsten Winkler

6

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11 November 2017

Matthias Kaup

7

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11 November 2017

Markus Berger

8

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11 November 2017

Volker Sandig

10

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11 November 2017

15 July 2010

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11 November 2017

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11 November 2017

20

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11 November 2017

12

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11 November 2017

1607-1618

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Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7.

11 November 2017

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https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

The biosynthesis of GDP-L-colitose: C-3 deoxygenation is catalyzed by a unique coenzyme B6-dependent enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Structural and enzymatic characterization of human recombinant GDP-D-mannose-4,6-dehydratase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

The use of osazones as matrices for the matrix-assisted laser desorption/ionization mass spectrometry of carbohydrates

21 January 2018

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https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

The IgG Fc receptor family

21 January 2018

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https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Post-translational modifications differentially affect IgG1 conformation and receptor binding.

21 January 2018

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https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Double knockdown of alpha1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types

21 January 2018

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https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Comparison of cell lines for stable production of fucose-negative antibodies with enhanced ADCC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Establishment of a GDP-mannose 4,6-dehydratase (GMD) knockout host cell line: a new strategy for generating completely non-fucosylated recombinant therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-d-rhamnose biosynthesis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Mechanism and active site residues of GDP-fucose synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

"Glyco-peakfinder"--de novo composition analysis of glycoconjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Cloning and functional expression of a novel GDP-6-deoxy-D-talose synthetase from Actinobacillus actinomycetemcomitans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Enhancement of the antibody-dependent cellular cytotoxicity of low-fucose IgG1 Is independent of FcgammaRIIIa functional polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Enhanced natural killer cell binding and activation by low-fucose IgG1 antibody results in potent antibody-dependent cellular cytotoxicity induction at lower antigen density

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

IgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharides

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

The structure of a human type III Fcgamma receptor in complex with Fc

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Mechanisms of Activation of Human Natural Killer Cells Against Tumor and Virus-infected Cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Positive genetic selection for gene disruption in mammalian cells by homologous recombination

21 January 2018

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https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Expression, purification and characterization of GDP-D-mannose 4,6-dehydratase from Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

A nonfucosylated anti-HER2 antibody augments antibody-dependent cellular cytotoxicity in breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Effect of gamma rays at the dihydrofolate reductase locus: deletions and inversions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

Crystal structure of a tetrameric GDP-D-mannose 4,6-dehydratase from a bacterial GDP-D-rhamnose biosynthetic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FGLYCOB%2FCWQ109

21 January 2018

Identifiers

DOI

10.1093/GLYCOB/CWQ109

1 reference

11 November 2017

1 reference