Differential effects of quercetin, apigenin and genistein on signalling pathways of protease-activated receptors PAR(1) and PAR(4) in platelets. (Q42951363)

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scientific article published on 8 October 2009

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English	Differential effects of quercetin, apigenin and genistein on signalling pathways of protease-activated receptors PAR(1) and PAR(4) in platelets.	scientific article published on 8 October 2009

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9 February 2020

Differential effects of quercetin, apigenin and genistein on signalling pathways of protease-activated receptors PAR(1) and PAR(4) in platelets (English)

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9 February 2020

Leyre Navarro-Nuñez

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9 February 2020

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9 February 2020

Vicente Vicente

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9 February 2020

Maria L. Lozano

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9 February 2020

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J A Guerrero

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9 February 2020

C Martínez

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9 February 2020

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8 October 2009

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9 February 2020

British Journal of Pharmacology

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9 February 2020

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9 February 2020

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9 February 2020

1548-1556

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9 February 2020

Protease-activated receptors as targets for antiplatelet therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets

1 reference

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26 May 2018

Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.

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26 May 2018

Selectivity-determining residues in Plk1

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26 May 2018

Flavonoids inhibit the platelet TxA(2) signalling pathway and antagonize TxA(2) receptors (TP) in platelets and smooth muscle cells.

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26 May 2018

Exploring the specificity of the PI3K family inhibitor LY294002.

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26 May 2018

PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation

1 reference

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26 May 2018

P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation

1 reference

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26 May 2018

Protease-activated receptors in hemostasis, thrombosis and vascular biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

Peptide-derived protease-activated receptor-1 (PAR-1) antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

ADP secretion and subsequent P2Y12 receptor signalling play a crucial role in thrombin-induced ERK2 activation in human platelets

1 reference

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26 May 2018

Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice

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26 May 2018

A FRET-based assay platform for ultra-high density drug screening of protein kinases and phosphatases

1 reference

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26 May 2018

Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

Thrombin and platelet activation

1 reference

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26 May 2018

Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer

1 reference

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26 May 2018

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

A dual thrombin receptor system for platelet activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

Genistein, a specific inhibitor of tyrosine-specific protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

26 May 2018

Thromboxane A2 receptor antagonism by flavonoids: structure-activity relationships

1 reference

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16 August 2018

The Src requirement for washed platelet aggregation and dense granule secretion in response to stimulation by a low level gamma-thrombin

1 reference

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16 August 2018

Guide to Receptors and Channels (GRAC), 3rd edition

1 reference

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16 August 2018

Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

16 August 2018

Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795221

16 August 2018

Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway

1 reference

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16 August 2018

Dietary phytoestrogens and their synthetic structural analogues as calcium channel blockers in human platelets

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16 August 2018

Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin

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16 August 2018

Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19814731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of genistein, a tyrosine kinase inhibitor, on platelet functions. Genistein attenuates thrombin-induced Ca2+ mobilization in human platelets by affecting polyphosphoinositide turnover

1 reference

https://pubmed.ncbi.nlm.nih.gov/19814731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of ADP interaction with P2Y12 receptor in the maintenance of alpha(IIb)beta3 activation: association with Rap1B activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19814731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19814731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19814731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19814731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of genistein on platelet function are due to thromboxane receptor antagonism rather than inhibition of tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19814731

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.2009.00440.X

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9 February 2020

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9 February 2020

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9 February 2020

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