Inhibition of interleukin-1β converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones (Q42950789)

11 November 2017

Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones (English)

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11 November 2017

Inhibition of interleukin-1β converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones (English)

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

14 June 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20674352

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Catherine Kostlan

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Bradley Caprathe

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object named as

Bradley Caprathe

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author name string

Paul Galatsis

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11 November 2017

Dennis Downing

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11 November 2017

John Gilmore

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11 November 2017

William Harter

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Sheryl Hays

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Kristin Linn

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Elizabeth Lunney

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Kim Para

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Anthony Thomas

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Joseph Warmus

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11 November 2017

Hamish Allen

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11 November 2017

Kenneth Brady

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11 November 2017

Robert Talanian

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11 November 2017

Nigel Walker

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11 November 2017

language of work or name

English

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publication date

11 July 2010

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full work available at URL

11 November 2017

https://api.elsevier.com/content/article/PII:S0960894X1000987X?httpAccept=text/xml

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

https://api.elsevier.com/content/article/PII:S0960894X1000987X?httpAccept=text/plain

14 June 2024

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Bioorganic & Medicinal Chemistry Letters

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published in

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11 November 2017

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11 November 2017

5089-5094

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

11 November 2017

1

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

The caspase family of cysteine proteases

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Evolution of interleukin-1beta

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

IL-1 in chronic arthritis, lessons from animal models

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

ICE/Caspase-1 inhibitors as novel anti-inflammatory drugs

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention

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Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation

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Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs

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New approaches and therapeutics targeting apoptosis in disease

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Structure and mechanism of interleukin-1 beta converting enzyme

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis

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1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase

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20

1 reference

https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group

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21

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Synthesis and structure-activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Three-dimensional quantitative structure-activity relationship of interleukin 1-beta converting enzyme inhibitors: A comparative molecular field analysis study

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

The design and synthesis of sulfonamides as caspase-1 inhibitors

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

Bimodal inhibition of caspase-1 by aryloxymethyl and acyloxymethyl ketones.

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https://api.crossref.org/works/10.1016/J.BMCL.2010.07.031

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Identifiers

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11 November 2017

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