Genetic modeling of Li-Fraumeni syndrome in zebrafish (Q42936703)

11 November 2017

Genetic modeling of Li-Fraumeni syndrome in zebrafish (English)

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11 November 2017

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GOA release 2020-03-11

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John M Parant

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11 November 2017

Stephen A George

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11 November 2017

Joseph A Holden

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3

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11 November 2017

H Joseph Yost

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11 November 2017

1 January 2010

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Disease Models & Mechanisms

11 November 2017

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11 November 2017

3

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11 November 2017

1-2

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11 November 2017

45-56

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describes a project that uses

11 November 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2806900/fullTextXML

inferred from PubMed Central ID database lookup

cites work

A rapid and efficient method of genotyping zebrafish mutants

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Zebrafish as a cancer model

27 May 2018

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The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

27 May 2018

1 reference

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Detection of the p53 response in zebrafish embryos using new monoclonal antibodies

27 May 2018

1 reference

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New waves of discovery: modeling cancer in zebrafish

27 May 2018

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Inherited cancer susceptibility syndromes in paediatric practice

27 May 2018

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A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

27 May 2018

1 reference

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Lessons from p53 in non-mammalian models.

27 May 2018

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Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia

27 May 2018

1 reference

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tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

27 May 2018

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Many ribosomal protein genes are cancer genes in zebrafish

27 May 2018

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In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish

27 May 2018

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27 May 2018

MDM2, an introduction.

1 reference

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Germline TP53 mutations and Li-Fraumeni syndrome

27 May 2018

1 reference

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

27 May 2018

1 reference

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Genetics of childhood cancer.

27 May 2018

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The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis

27 May 2018

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The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

27 May 2018

1 reference

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Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status.

27 May 2018

1 reference

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Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

27 May 2018

1 reference

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Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome

27 May 2018

1 reference

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P53 germline mutations in childhood cancers and cancer risk for carrier individuals

27 May 2018

1 reference

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Drosophila p53 binds a damage response element at the reaper locus

27 May 2018

1 reference

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Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.

27 May 2018

1 reference

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p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines

27 May 2018

1 reference

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Tumors associated with p53 germline mutations: a synopsis of 91 families.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Gain of function mutations in p53.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Tumor spectrum analysis in p53-mutant mice

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Heterogeneity in Li-Fraumeni families: p53 mutation analysis and immunohistochemical staining

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

The tumor suppressor p53 regulates its own transcription

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Thymocyte apoptosis induced by p53-dependent and independent pathways.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Is CHEK2 a cause of the Li Fraumeni syndrome?

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806900

Xenopus embryos regulate the nuclear localization of XMyoD

1 December 2018

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12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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12 December 2020

Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets

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12 December 2020

Production of clones of homozygous diploid zebra fish (Brachydanio rerio)

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12 December 2020

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

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12 December 2020

Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23

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12 December 2020

Identifiers

DOI

10.1242/DMM.003749

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11 November 2017

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11 November 2017

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