Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania. (Q42849844)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21646479%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania (English)

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3 February 2020

1 reference

1 reference

6

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José María Pérez-Victoria

3 February 2020

1

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3 February 2020

Marta Martínez-García

4

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3 February 2020

Santiago Castanys

7

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3 February 2020

Francisco Gamarro

8

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3 February 2020

author name string

Boris I Bavchvarov

2

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3 February 2020

Iván R Torrecillas

3

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3 February 2020

Carmen López-Martín

5

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3 February 2020

language of work or name

English

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publication date

6 June 2011

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Antimicrobial Agents and Chemotherapy

3 February 2020

published in

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3 February 2020

volume

55

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3 February 2020

issue

8

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3 February 2020

page(s)

3838-3844

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Ligand docking and binding site analysis with PyMOL and Autodock/Vina

3 February 2020

cites work

1 reference

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Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement

27 May 2018

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Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.

27 May 2018

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Mutational analysis of ABC proteins

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Flexibility in the ABC transporter MsbA: Alternating access with a twist

27 May 2018

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Computation of octanol-water partition coefficients by guiding an additive model with knowledge

27 May 2018

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Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites.

27 May 2018

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Structure of a bacterial multidrug ABC transporter

27 May 2018

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Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux

27 May 2018

1 reference

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The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux

27 May 2018

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Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.

27 May 2018

1 reference

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Chloroquine and primaquine: combining old drugs as a new weapon against falciparum malaria?

27 May 2018

1 reference

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Primaquine synergises the activity of chloroquine against chloroquine-resistant P. falciparum.

27 May 2018

1 reference

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Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranes

27 May 2018

1 reference

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Orally effective drugs for kala-azar (visceral leishmaniasis): focus on miltefosine and sitamaquine

27 May 2018

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Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major

27 May 2018

1 reference

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Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: a search for reversal agents

27 May 2018

1 reference

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Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters

27 May 2018

1 reference

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ABC transporters in the protozoan parasite Leishmania.

27 May 2018

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27 May 2018

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Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator

27 May 2018

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High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin

27 May 2018

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Interactions of racemic mefloquine and its enantiomers with P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT.

27 May 2018

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Reversal of MRP-mediated doxorubicin resistance with quinoline-based drugs

27 May 2018

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Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

27 May 2018

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27 May 2018

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Correlation between the affinity of flavonoids binding to the cytosolic site of Leishmania tropica multidrug transporter and their efficiency to revert parasite resistance to daunomycin

27 May 2018

1 reference

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Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line.

27 May 2018

1 reference

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Co-amplification of the gamma-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae.

27 May 2018

1 reference

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Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine.

27 May 2018

1 reference

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Comparative protein modelling by satisfaction of spatial restraints

27 May 2018

1 reference

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Pharmacology of drugs that alter multidrug resistance in cancer

27 May 2018

1 reference

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Human P-glycoprotein is active when the two halves are clamped together in the closed conformation

27 May 2018

1 reference

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Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.

16 August 2018

1 reference

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A novel ATP-binding cassette transporter, ABCG6 is involved in chemoresistance of Leishmania

16 August 2018

1 reference

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A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.

16 August 2018

1 reference

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Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani.

16 August 2018

1 reference

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SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrug-resistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter.

16 August 2018

1 reference

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Antifungal drug resistance in pathogenic fungi

16 August 2018

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New Natural Sesquiterpenes as Modulators of Daunomycin Resistance in a Multidrug-ResistantLeishmaniatropicaLine‖,⊥

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21646479

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Communication between multiple drug binding sites on P-glycoprotein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21646479

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.00065-11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21646479%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21646479%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

21646479

1 reference