Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-zeta (Q42828579)

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scientific article published on 28 May 2004

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English	Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-zeta	scientific article published on 28 May 2004

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-zeta (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

1 reference

based on heuristic

inferred from title

insulin resistance

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based on heuristic

inferred from title

author name string

R Ben-Romano

1

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

A Rudich

2

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

A Tirosh

3

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

R Potashnik

4

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

T Sasaoka

5

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

K Riesenberg

6

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

F Schlaeffer

7

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

N Bashan

8

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

publication date

28 May 2004

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Europe PubMed Central

PubMed publication ID

8 November 2017

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Europe PubMed Central

PubMed publication ID

8 November 2017

47

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Europe PubMed Central

PubMed publication ID

8 November 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

1107-1117

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Europe PubMed Central

PubMed publication ID

8 November 2017

https://scigraph.springernature.com/pub.10.1007/s00125-004-1408-5

0 references

Lipodystrophy-associated morphological, cholesterol and triglyceride abnormalities in a population-based HIV/AIDS treatment database

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

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A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

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A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

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The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance in the HIV-lipodystrophy syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical perspectives on HIV-associated lipodystrophy syndrome: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

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Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of adipocyte differentiation by HIV protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indinavir induces acute and reversible peripheral insulin resistance in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of insulin resistance caused by HIV protease inhibitor therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calmodulin antagonists inhibit insulin-stimulated GLUT4 (glucose transporter 4) translocation by preventing the formation of phosphatidylinositol 3,4,5-trisphosphate in 3T3L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation of mitogen-activated protein kinase by insulin and epidermal growth factor in 3T3-L1 adipocytes: a possible involvement of PI3-kinase in the activation of the MAP kinase by insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in our understanding of insulin action and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective Akt activation is associated with glucose- but not glucosamine-induced insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HIV protease inhibitor nelfinavir induces insulin resistance and increases basal lipolysis in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the Src homology 2 (SH2) domain and C-terminus tyrosine phosphorylation sites of SH2-containing inositol phosphatase (SHIP) in the regulation of insulin-induced mitogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiated 3T3L1 adipocytes are composed of heterogenous cell populations with distinct receptor tyrosine kinase signaling properties.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigating the cellular targets of HIV protease inhibitors: implications for metabolic disorders and improvements in drug therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic disorders among HIV-infected patients treated with protease inhibitors: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane localization of 3-phosphoinositide-dependent protein kinase-1 stimulates activities of Akt and atypical protein kinase C but does not stimulate glucose transport and glycogen synthesis in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms for the deterioration in glucose tolerance associated with HIV protease inhibitor regimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoatrophy revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of insulin resistance: modulation of the insulin signal at receptor level

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin action and insulin resistance in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15168016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-004-1408-5

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

ResearchGate publication ID

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