DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. (Q42826326)

8 November 2017

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. (English)

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8 November 2017

7

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8 November 2017

1

Matthias Lauth

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8 November 2017

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Volker Fendrich

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8 November 2017

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Rune Toftgård

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8 November 2017

Asa Bergström

2

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8 November 2017

Takashi Shimokawa

3

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8 November 2017

Ulrica Tostar

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8 November 2017

Qianren Jin

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8 November 2017

Mariano Barbacid

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8 November 2017

30 May 2010

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Nature Structural & Molecular Biology

8 November 2017

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8 November 2017

17

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8 November 2017

718-725

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8 November 2017

6

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https://scigraph.springernature.com/pub.10.1038/nsmb.1833

8 November 2017

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cites work

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Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

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Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

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A paracrine requirement for hedgehog signalling in cancer

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Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice

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Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

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Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

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Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

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Hedgehog signaling is required for effective regeneration of exocrine pancreas

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Hyperactive Ras in developmental disorders and cancer

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The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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Small molecule modulation of Smoothened activity

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Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

31 March 2020

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Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice

31 March 2020

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

31 March 2020

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PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts

31 March 2020

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Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli.

31 March 2020

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The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer

31 March 2020

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Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1

31 March 2020

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Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

31 March 2020

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Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines

31 March 2020

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Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia

31 March 2020

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Hedgehog signalling in the mouse requires intraflagellar transport proteins

31 March 2020

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GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

31 March 2020

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Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo

31 March 2020

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Hedgehog pathway expression in heterogeneous pancreatic adenocarcinoma: implications for the molecular analysis of clinically available biopsies.

31 March 2020

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Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines

31 March 2020

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Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells

31 March 2020

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Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy

31 March 2020

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SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell

31 March 2020

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Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells

31 March 2020

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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

31 March 2020

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Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells.

31 March 2020

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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

31 March 2020

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Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer

31 March 2020

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Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling

31 March 2020

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GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB.1833

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8 November 2017

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