The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase. (Q42803344)

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scientific article published on 30 January 2017

Language	Label	Description	Also known as
English	The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase.	scientific article published on 30 January 2017

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scholarly article

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10 April 2020

The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase (English)

1 reference

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10 April 2020

1

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10 April 2020

Matthew R Pratt

5

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10 April 2020

author name string

Anna R Batt

2

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10 April 2020

Kelly N Chuh

3

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10 April 2020

Marisol X Navarro

4

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10 April 2020

publication date

30 January 2017

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10 April 2020

ACS Chemical Biology

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10 April 2020

12

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10 April 2020

3

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10 April 2020

787-794

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10 April 2020

Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification

1 reference

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12 December 2020

based on heuristic

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Finding the right (bioorthogonal) chemistry.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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The emerging significance of O-GlcNAc in cellular regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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An OGA-Resistant Probe Allows Specific Visualization and Accurate Identification of O-GlcNAc-Modified Proteins in Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A chemical approach for identifying O-GlcNAc-modified proteins in cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-GlcNAcase is essential for embryonic development and maintenance of genomic stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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Chemical reporter for visualizing metabolic cross-talk between carbohydrate metabolism and protein modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

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N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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O-GlcNAc in cancer biology

1 reference

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12 December 2020

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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

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Robust fluorescent detection of protein fatty-acylation with chemical reporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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Cell surface engineering by a modified Staudinger reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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The subcellular distribution of terminal N-acetylglucosamine moieties. Localization of a novel protein-saccharide linkage, O-linked GlcNAc.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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Chemical reporters for biological discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical Methods for Encoding and Decoding of Posttranslational Modifications

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural snapshots of the reaction coordinate for O-GlcNAc transferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

1 reference

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12 December 2020

based on heuristic

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Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regioisomeric SCFA attachment to hexosamines separates metabolic flux from cytotoxicity and MUC1 suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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Chemical methods for the proteome-wide identification of posttranslationally modified proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

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An efficient, inexpensive, and shelf-stable diazotransfer reagent: imidazole-1-sulfonyl azide hydrochloride

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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Structural metrics relationships in covalently bonded organic azides

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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Investigating cellular metabolism of synthetic azidosugars with the Staudinger ligation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

based on heuristic

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Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

1 reference

https://pubmed.ncbi.nlm.nih.gov/28135057

12 December 2020

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Identifiers

10.1021/ACSCHEMBIO.6B00877

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28135057%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28135057%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

Europe PubMed Central

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10 April 2020

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