Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase (Q42788863)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24976069%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase (English)

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21 March 2020

2

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21 March 2020

author name string

Karl R Schmitz

series ordinal

1

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21 March 2020

language of work or name

English

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publication date

13 July 2014

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21 March 2020

published in

Molecular Microbiology

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21 March 2020

volume

93

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21 March 2020

issue

4

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21 March 2020

page(s)

617-628

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Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus

21 March 2020

cites work

1 reference

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Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition

27 May 2018

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Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase

27 May 2018

1 reference

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Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities

27 May 2018

1 reference

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Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine.

27 May 2018

1 reference

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Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection

27 May 2018

1 reference

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Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein

27 May 2018

1 reference

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The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.

27 May 2018

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Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2.

27 May 2018

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Role of intracellular proteases in the antibiotic resistance, motility, and biofilm formation of Pseudomonas aeruginosa

27 May 2018

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Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target

27 May 2018

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Structural insights into the conformational diversity of ClpP from Bacillus subtilis

27 May 2018

1 reference

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Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

27 May 2018

1 reference

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High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

27 May 2018

1 reference

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A conformational switch underlies ClpP protease function

27 May 2018

1 reference

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Structure and mechanism of the hexameric MecA-ClpC molecular machine

27 May 2018

1 reference

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Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.

27 May 2018

1 reference

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Structural and theoretical studies indicate that the cylindrical protease ClpP samples extended and compact conformations

27 May 2018

1 reference

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Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

27 May 2018

1 reference

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A new bioinformatics analysis tools framework at EMBL-EBI.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Control of substrate gating and translocation into ClpP by channel residues and ClpX binding.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Extensively drug-resistant tuberculosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Clustal W and Clustal X version 2.0

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

ClpP: a distinctive family of cylindrical energy-dependent serine proteases

27 May 2018

1 reference

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Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1

27 May 2018

1 reference

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Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

27 May 2018

1 reference

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Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX

27 May 2018

1 reference

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Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing

27 May 2018

1 reference

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Antibacterial resistance worldwide: causes, challenges and responses

27 May 2018

1 reference

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Sculpting the proteome with AAA(+) proteases and disassembly machines.

27 May 2018

1 reference

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The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Crystal Structure of ClpX Molecular Chaperone from Helicobacter pylori

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Genes required for mycobacterial growth defined by high density mutagenesis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

SsrA-mediated tagging in Bacillus subtilis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

The crisis in antibiotic resistance

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

The mechanism of caseinolytic protease (ClpP) inhibition

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Interaction specificity between the chaperone and proteolytic components of the cyanobacterial Clp protease

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Site-directed methyl group labeling as an NMR probe of structure and dynamics in supramolecular protein systems: applications to the proteasome and to the ClpP protease.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Communication between ClpX and ClpP during substrate processing and degradation

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Energy-dependent degradation: Linkage between ClpX-catalyzed nucleotide hydrolysis and protein-substrate processing.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Dynamics of substrate denaturation and translocation by the ClpXP degradation machine

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Molecular properties of ClpAP protease of Escherichia coli: ATP-dependent association of ClpA and clpP.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Requirement of ATP hydrolysis for assembly of ClpA/ClpP complex, the ATP-dependent protease Ti in Escherichia coli.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Scanning transmission electron microscopy and small-angle scattering provide evidence that native Escherichia coli ClpP is a tetradecamer with an axial pore.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4131744

Coupled assay of Na+,K+-ATPase activity

16 August 2018

1 reference

12 December 2020

Enzymatic and structural similarities between the Escherichia coli ATP-dependent proteases, ClpXP and ClpAP

1 reference

12 December 2020

Vibralactone as a tool to study the activity and structure of the ClpP1P2 complex from Listeria monocytogenes

1 reference

12 December 2020

Antibiotic resistance: global response needed

1 reference

12 December 2020

Distinctive types of ATP-dependent Clp proteases in cyanobacteria

1 reference

12 December 2020

Identifiers

DOI

10.1111/MMI.12694

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24976069%20AND%20SRC:MED&resulttype=core&format=json

release_4qbjg2dfibb3vbpczfwwug53bm

21 March 2020

Fatcat ID

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Fatcat

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24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24976069%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference