Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells (Q42776481)

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scientific article published on January 2009

Language	Label	Description	Also known as
English	Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells	scientific article published on January 2009

Statements

scholarly article

1 reference

Europe PubMed Central

7 November 2017

Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells (English)

1 reference

Europe PubMed Central

7 November 2017

0 references

author name string

Christina Donnelly

1

1 reference

Europe PubMed Central

7 November 2017

Arne M Olsen

2

1 reference

Europe PubMed Central

7 November 2017

Lionel D Lewis

3

1 reference

Europe PubMed Central

7 November 2017

Burton L Eisenberg

4

1 reference

Europe PubMed Central

7 November 2017

Alan Eastman

5

1 reference

Europe PubMed Central

7 November 2017

William B Kinlaw

6

1 reference

Europe PubMed Central

7 November 2017

publication date

1 January 2009

1 reference

Europe PubMed Central

7 November 2017

Nutrition and Cancer

1 reference

Europe PubMed Central

7 November 2017

61

1 reference

Europe PubMed Central

7 November 2017

1

1 reference

Europe PubMed Central

7 November 2017

114-122

1 reference

Europe PubMed Central

7 November 2017

The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

1 reference

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27 May 2018

The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Spot 14: A marker of aggressive breast cancer and a potential therapeutic target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Increased lipogenesis in cancer cells: new players, novel targets.

1 reference

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27 May 2018

Fatty acid synthase and cancer: new application of an old pathway

1 reference

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27 May 2018

Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

1 reference

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27 May 2018

Biological effects of conjugated linoleic acids in health and disease

1 reference

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27 May 2018

Metastasis predictive signature profiles pre-exist in normal tissues

1 reference

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27 May 2018

ATP citrate lyase inhibition can suppress tumor cell growth

1 reference

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27 May 2018

RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells

1 reference

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27 May 2018

Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene

1 reference

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27 May 2018

Prevention of mammary cancer with conjugated linoleic acid: role of the stroma and the epithelium

1 reference

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27 May 2018

Nutritional regulation of milk fat synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

The biologically active isomers of conjugated linoleic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Reduction of murine mammary tumor metastasis by conjugated linoleic acid

1 reference

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27 May 2018

Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Progestins and androgens increase expression of Spot 14 in T47-D breast tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

"Spot 14" protein: a metabolic integrator in normal and neoplastic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Direct evidence for a role of the "spot 14" protein in the regulation of lipid synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Hormonal regulation of the S14 gene in 3T3-F442A cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

27 May 2018

SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

16 August 2018

S14 protein in breast cancer cells: direct evidence of regulation by SREBP-1c, superinduction with progestin, and effects on cell growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

16 August 2018

Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

16 August 2018

Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

16 August 2018

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

16 August 2018

Conjugated linoleic acid isomers and mammary cancer prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

16 August 2018

Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

16 August 2018

Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872989

16 August 2018

Expression of "Spot 14" (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker

1 reference

https://pubmed.ncbi.nlm.nih.gov/19116881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19116881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19116881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"Spot 14" protein functions at the pretranslational level in the regulation of hepatic metabolism by thyroid hormone and glucose

1 reference

https://pubmed.ncbi.nlm.nih.gov/19116881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19116881

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1080/01635580802348666

1 reference

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https://api.fatcat.wiki/v0/release/mgsw77iukveyndazfsfu2fpwoy

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https://api.fatcat.wiki/v0/release/mgsw77iukveyndazfsfu2fpwoy

30 July 2022

based on heuristic

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https://api.fatcat.wiki/v0/release/mgsw77iukveyndazfsfu2fpwoy

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