Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus (Q42754399)

6 November 2017

Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus (English)

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6 November 2017

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1

Helena Domin

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PubMed ID

21273662

6 November 2017

Krystyna Gołembiowska

series ordinal

3

object named as

Krystyna Gołembiowska

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6 November 2017

5

Anna Dziubina

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6 November 2017

6

Maria Śmiałowska

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6 November 2017

Barbara Zięba

2

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PubMed ID

21273662

6 November 2017

Magdalena Kowalska

series ordinal

4

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6 November 2017

1 November 2010

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6 November 2017

Pharmacological Reports

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6 November 2017

62

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6 November 2017

6

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6 November 2017

1051-1061

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Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro

6 November 2017

1 reference

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7 January 2021

In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine).

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

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7 January 2021

Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission

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7 January 2021

Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety

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7 January 2021

Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders

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7 January 2021

Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Regulation of glutamate release by presynaptic kainate receptors in the hippocampus

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Excitotoxic cell death

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Pharmacology and functions of metabotropic glutamate receptors

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7 January 2021

[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

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7 January 2021

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices

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7 January 2021

Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Neuroprotective activity of metabotropic glutamate receptor ligands.

1 reference

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7 January 2021

Effect of the adenosine A2A receptor antagonist 8-(3-chlorostyryl)caffeine on L-DOPA biotransformation in rat striatum

1 reference

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7 January 2021

Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats

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7 January 2021

The efficiency of systematic sampling in stereology and its prediction.

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7 January 2021

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

1 reference

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7 January 2021

Neuroprotective effect caused by MPEP, an antagonist of metabotropic glutamate receptor mGluR5, on seizures induced by pilocarpine in 21-day-old rats

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Liquid chromatographic determination of amino acids after gas-phase hydrolysis and derivatization with (dimethylamino)azobenzenesulfonyl chloride

1 reference

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7 January 2021

Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127.

1 reference

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7 January 2021

Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Neuroprotective potential of group I metabotropic glutamate receptor antagonists in two ischemic models.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Kainate receptors in hippocampal CA3 subregion: evidence for a role in regulating neurotransmitter release

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Calcium and neurodegeneration

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex.

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Clinical experience with excitatory amino acid antagonist drugs

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7 January 2021

Distribution of mGluR1alpha and mGluR5 immunolabeling in primate prefrontal cortex

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7 January 2021

Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.

1 reference

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7 January 2021

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats.

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Degeneration of dopaminergic mesocortical neurons and activation of compensatory processes induced by a long-term paraquat administration in rats: implications for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long-term paraquat administration in rats: an animal model of preclinical stages of Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

The mGlu5 receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A2A receptors

1 reference

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7 January 2021

Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Antidepressants for the new millennium

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7 January 2021

The pharmacological manipulation of glutamate receptors and neuroprotection

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https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo.

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7 January 2021

Neuroprotective effects of neuropeptide Y-Y2 and Y5 receptor agonists in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1734-1140%2810%2970367-4

7 January 2021

10.1016/S1734-1140(10)70367-4

Identifiers

DOI

1 reference

6 November 2017

1 reference

PubMed ID

21273662