Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2. (Q42725814)

5 November 2017

title

Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2. (English)

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5 November 2017

28

A Tefferi

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A V Purandare

1

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T M McDevitt

2

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H Wan

3

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D You

4

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B Penhallow

5

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X Han

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R Vuppugalla

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Y Zhang

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S U Ruepp

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G L Trainor

10

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L Lombardo

11

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D Pedicord

12

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M M Gottardis

13

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P Ross-Macdonald

14

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H de Silva

15

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J Hosbach

16

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S L Emanuel

17

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Y Blat

18

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E Fitzpatrick

19

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T L Taylor

20

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K W McIntyre

21

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E Michaud

22

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C Mulligan

23

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F Y Lee

24

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A Woolfson

25

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T L Lasho

26

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A Pardanani

27

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M V Lorenzi

29

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5 November 2017

publication date

21 October 2011

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5 November 2017

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5 November 2017

volume

26

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issue

2

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page(s)

280-288

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https://scigraph.springernature.com/pub.10.1038/leu.2011.292

5 November 2017

exact match

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The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

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CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

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TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

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Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein

21 January 2018

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Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling

21 January 2018

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Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.

21 January 2018

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21 January 2018

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Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation

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Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors

21 January 2018

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The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

21 January 2018

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Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo

21 January 2018

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The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

21 January 2018

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The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors

21 January 2018

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Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.

21 January 2018

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Activated STAT1 and STAT5 transcription factors in extramedullary hematopoietic tissue in a polycythemia vera patient carrying the JAK2 V617F mutation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/LEU.2011.292

1 reference

Dimensions Publication ID

5 November 2017

1014613085

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1 reference