The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells (Q42705821)

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scientific article published on 30 April 2014

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English	The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells	scientific article published on 30 April 2014

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scholarly article

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Europe PubMed Central

5 November 2017

The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells (English)

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5 November 2017

Carlos López Otín

9

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Sílvia Xargay-Torrent

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1 June 2020

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M López-Guerra

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L Rosich

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A Montraveta

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J Roldán

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A Matas-Céspedes

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N Villamor

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M Aymerich

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P Pérez-Galán

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30 April 2014

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5 November 2017

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96-106

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1

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1 June 2020

https://scigraph.springernature.com/pub.10.1038/leu.2014.143

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New prognostic markers in chronic lymphocytic leukemia

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21 January 2018

From pathogenesis to treatment of chronic lymphocytic leukaemia

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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

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21 January 2018

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

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21 January 2018

POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia

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SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

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Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

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21 January 2018

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

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21 January 2018

Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients

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21 January 2018

Notch signalling: a simple pathway becomes complex

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Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia

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NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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21 January 2018

Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design

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21 January 2018

Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia

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The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells

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Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters

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21 January 2018

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

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https://api.crossref.org/works/10.1038%2FLEU.2014.143

21 January 2018

Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression response

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https://api.crossref.org/works/10.1038%2FLEU.2014.143

21 January 2018

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

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21 January 2018

γ-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation.

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21 January 2018

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

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The role of HRK gene in human cancer

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Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs

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Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy.

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21 January 2018

Role of angiogenesis in chronic lymphocytic leukemia

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21 January 2018

Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity

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21 January 2018

Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice.

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21 January 2018

Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain

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21 January 2018

The role of matrix metalloproteinase 9 in the pathogenesis of chronic lymphocytic leukaemia.

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21 January 2018

Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.

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21 January 2018

Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis

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21 January 2018

Specific roles of Rac1 and Rac2 in motile functions of HT1080 fibrosarcoma cells

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21 January 2018

ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia

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21 January 2018

Notch1 is involved in migration and invasion of human breast cancer cells

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12 December 2020

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Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9

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12 December 2020

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Activation and proliferation of follicular dendritic cell-like cells by activated T lymphocytes.

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12 December 2020

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Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

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12 December 2020

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Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

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12 December 2020

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