Reassessing models of hepatic extraction (Q42704731)

5 November 2017

Reassessing models of hepatic extraction (English)

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5 November 2017

D Ridgway

1

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5 November 2017

J A Tuszynski

series ordinal

2

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5 November 2017

Y K Tam

series ordinal

3

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5 November 2017

1 March 2003

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Journal of Biological Physics

5 November 2017

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5 November 2017

29

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5 November 2017

1

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5 November 2017

1-21

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https://scigraph.springernature.com/pub.10.1023/a:1022531403741

5 November 2017

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cites work

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Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

27 May 2018

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Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.

27 May 2018

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The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

27 May 2018

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Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

27 May 2018

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Physiologically based pharmacokinetic models: mathematical fundamentals and simulation implementations

27 May 2018

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Saturation kinetics in hepatic drug removal: a statistical approach to functional heterogeneity

27 May 2018

1 reference

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Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in rats

27 May 2018

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A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

27 May 2018

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On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination

27 May 2018

1 reference

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Basic concepts in pharmaco-dynamic modeling

27 May 2018

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Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol, and antipyrine in the rat.

27 May 2018

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Noncompartmental versus compartmental modelling in clinical pharmacokinetics

27 May 2018

1 reference

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Models of hepatic drug elimination

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456842

Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance

27 May 2018

1 reference

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Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

27 May 2018

1 reference

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Problems of mixed boundary conditions for convection-dispersion models in the analysis of local pharmacokinetics.

27 May 2018

1 reference

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Commentary: using the convection-dispersion model and transit time density functions in the analysis of organ distribution kinetics.

16 August 2018

1 reference

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Notes on the inverse Gaussian distribution and choice of boundary conditions for the dispersion model in the analysis of local pharmacokinetics.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456842

Interconnected-tubes model of hepatic elimination: steady-state considerations.

16 August 2018

1 reference

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Interconnected-tubes model of hepatic elimination.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456842

Kinetics of diazepam metabolism in rat hepatic microsomes and hepatocytes and their use in predicting in vivo hepatic clearance.

16 August 2018

1 reference

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Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

16 August 2018

1 reference

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In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes

16 August 2018

1 reference

12 December 2020

Use of unbound drug concentration in blood to discriminate between two models of hepatic drug elimination

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12 December 2020

Pharmacokinetic correlation between in vitro hepatic microsomal enzyme kinetics and in vivo metabolism of imipramine and desipramine in rats

1 reference

12 December 2020

Controversy III: To model or not to model

1 reference

12 December 2020

Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination

1 reference

12 December 2020

A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

1 reference

12 December 2020

Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition

1 reference

12 December 2020

Metabolic disposition of tacrine in primary suspensions of rat hepatocyte and in single-pass perfused liver: in vitro/in vivo comparisons

1 reference

12 December 2020

A note on the interpretation of tracer dispersion in the liver

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1022531403741

1 reference

Dimensions Publication ID

5 November 2017

0 references

1 reference

5 November 2017

PubMed publication ID

23345816

1 reference