Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice (Q42617355)

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scientific article published on July 2004

Language	Label	Description	Also known as
English	Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice	scientific article published on July 2004

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scholarly article

1 reference

Europe PubMed Central

3 November 2017

Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice (English)

1 reference

Europe PubMed Central

3 November 2017

0 references

Patricia H Janak

2

1 reference

Europe PubMed Central

3 November 2017

author name string

Andrew J Mcgeehan

1

1 reference

Europe PubMed Central

3 November 2017

M Foster Olive

3

1 reference

Europe PubMed Central

3 November 2017

publication date

1 July 2004

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Europe PubMed Central

3 November 2017

Psychopharmacology

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Europe PubMed Central

3 November 2017

174

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Europe PubMed Central

3 November 2017

2

1 reference

Europe PubMed Central

3 November 2017

266-273

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Europe PubMed Central

3 November 2017

https://scigraph.springernature.com/pub.10.1007/s00213-003-1733-2

0 references

Group III metabotropic glutamate receptors and D1-like and D2-like dopamine receptors interact in the rat nucleus accumbens to influence locomotor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

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Neurochemical mechanisms involved in behavioral effects of amphetamines and related designer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

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Glutamatergic involvement in psychomotor stimulant action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution and clearance of cocaine in brain is influenced by genetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

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The role of the striatopallidal and extended amygdala systems in drug addiction

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

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Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

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[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

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The group I metabotropic glutamate receptor antagonist S-4-CPG modulates the locomotor response produced by the activation of D1-like, but not D2-like, dopamine receptors in the rat nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

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Strain differences in amphetamine sensitivity in mice. I. A diallel analysis of open field activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

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The neural substrates for the motor-activating properties of psychostimulants: a review of recent findings.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

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L-NAME and MK-801 attenuate sensitization to the locomotor-stimulating effect of cocaine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

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Group I metabotropic glutamate receptors in the monkey striatum: subsynaptic association with glutamatergic and dopaminergic afferents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

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Drugs of abuse: anatomy, pharmacology and function of reward pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of dopamine receptor subtypes occupied by intra-accumbens antagonists that reverse cocaine-induced locomotion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amphetamine increases the extracellular concentration of glutamate in striatum of the awake rat: involvement of high affinity transporter mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of NMDA receptor blockers on cocaine-stimulated locomotor activity in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of striatal dopamine release by metabotropic glutamate receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of excitatory amino acids in the regulation of dopamine synthesis and release in the neostriatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parallel strain-dependent effect of amphetamine on locomotor activity and dopamine release in the nucleus accumbens: an in vivo study in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic determinants of susceptibility to the rewarding and other behavioral actions of cocaine

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strain-specific effects of amphetamine on prepulse inhibition and patterns of locomotor behavior in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of the locomotor stimulant effects of amphetamine by group I, group II, and group III metabotropic glutamate receptor ligands in the rat nucleus accumbens: possible interactions with dopamine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MK-801 does not prevent acute stimulatory effects of amphetamine or cocaine on locomotor activity or extracellular dopamine levels in rat nucleus accumbens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamatergic mechanisms mediating stimulant and antipsychotic drug effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depletion of dopamine in the nucleus accumbens prevents the generation of locomotion by metabotropic glutamate receptor activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of MK-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of "reverse tolerance" to cocaine and amphetamine by MK-801.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strain-dependent behavioural sensitization to amphetamine: role of environmental influences

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of dopamine transporter and locomotor effects of cocaine, GBR 12909, epidepride, and SCH 23390 in C57BL and DBA mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of glutamate receptor subunit/subtype messenger RNAS for NMDAR1, GLuR1, GLuR2 and mGLuR5 by accumbal projection neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An analysis of cocaine effects on locomotor activities and heart rate in four inbred mouse strains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamatergic antagonists attenuate ability of dopamine uptake blockers to increase extracellular levels of dopamine: implications for tonic influence of glutamate on dopamine release.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of the locomotor stimulant effects of cocaine and methamphetamine by glutamate antagonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate-dopamine interactions mediate the effects of psychostimulant drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory amino acids and the actions of cocaine

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microinjection of cocaine into the nucleus accumbens elicits locomotor activation in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microinfusion of the metabotropic glutamate receptor agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid into the nucleus accumbens induces dopamine-dependent locomotor activation in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptors and the generation of locomotor activity: interactions with midbrain dopamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of cocaine related to its abuse

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the pallidal-thalamocortical circuit in adaptive behavior

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of metabotropic glutamate receptors in the rat nucleus accumbens increases locomotor activity in a dopamine-dependent manner.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular determinants of metabotropic glutamate receptor signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGlu5 receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A2A receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Injection of the protein kinase C inhibitor Ro31-8220 into the nucleus accumbens attenuates the acute response to amphetamine: tissue and behavioral studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Group II, but not group I, metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: studies on the involvement of dopamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology and functions of metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for sensitization of cocaine-induced nucleus accumbens glutamate release.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural systems for behavioral activation and reward

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central effects of scopolamine and (+)-amphetamine on locomotor activity: Interaction with strain and stress variables

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral effects of the selective blockade of metabotropic glutamate receptor subtype 5 in experimental hypoxia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential modulation of the D1-like- and D2-like dopamine receptor-induced locomotor responses by group II metabotropic glutamate receptors in the rat nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/14726993

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-003-1733-2

1 reference

Europe PubMed Central

3 November 2017

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https://api.fatcat.wiki/v0/release/s4u6kjpgmjb5jdlmu4pg33acse

24 November 2022

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mapped directly with Wikidata item

1 reference

Europe PubMed Central

3 November 2017

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