In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage (Q42616754)

3 November 2017

In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage (English)

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3 November 2017

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4

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3 November 2017

David A Rempe

1

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3 November 2017

Katherine M Lelli

series ordinal

2

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3 November 2017

Grace Vangeison

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3

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3 November 2017

Howard J Federoff

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5

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3 November 2017

language of work or name

English

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publication date

9 April 2007

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Journal of Biological Chemistry

3 November 2017

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3 November 2017

282

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3 November 2017

22

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3 November 2017

16187-16201

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Hypoxia and hypoxia-inducible factor modulated gene expression in brain: involvement in neuroprotection and cell death.

3 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

HIF-1 and p53: communication of transcription factors under hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Mdm2 and HIF-1alpha interaction in tumor cells during hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1alpha and its downstream target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Enhanced expression of p53 in reactive astrocytes following transient focal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Acute postnatal ablation of Hif-2alpha results in anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

HIF activation by pH-dependent nucleolar sequestration of VHL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Role of the von Hippel-Lindau tumour suppressor protein in the regulation of HIF-1alpha and its oxygen-regulated transactivation domains at high cell density.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702203200

21 January 2018

Identifiers

DOI

10.1074/JBC.M702203200

1 reference

3 November 2017

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