Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis (Q42583738)

3 November 2017

Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis (English)

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3 November 2017

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Fukun Guo

1

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3 November 2017

Shuangmin Zhang

2

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3 November 2017

Matthew Grogg

3

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3 November 2017

Jose A Cancelas

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3 November 2017

Melinda E Varney

5

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3 November 2017

Daniel T Starczynowski

6

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3 November 2017

Wei Du

7

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3 November 2017

Jun-Qi Yang

8

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3 November 2017

Wei Liu

9

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3 November 2017

George Thomas

10

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3 November 2017

Sara Kozma

11

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3 November 2017

Qishen Pang

12

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3 November 2017

Yi Zheng

13

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3 November 2017

language of work or name

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28 May 2013

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3 November 2017

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3 November 2017

98

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3 November 2017

9

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3 November 2017

1353-1358

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mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells

3 November 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

A critical role for Rictor in T lymphopoiesis

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

mTORC1 is essential for leukemia propagation but not stem cell self-renewal

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

Ex vivo rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

mTORC1 signaling governs hematopoietic stem cell quiescence

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

The multifaceted role of mTOR in cellular stress responses

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762090

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23716557

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3324/HAEMATOL.2012.080424

1 reference

3 November 2017

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3 November 2017

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