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general transcription factor IIB (Q425812)

From Wikidata
mammalian protein found in Homo sapiens
  • GTF2B
  • S300-II
  • RNA polymerase II transcription factor IIB
  • general transcription factor TFIIB
  • transcription initiation factor IIB
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    English
    general transcription factor IIB
    mammalian protein found in Homo sapiens
    • GTF2B
    • S300-II
    • RNA polymerase II transcription factor IIB
    • general transcription factor TFIIB
    • transcription initiation factor IIB

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    19 references
    retrieved
    1 January 2018
    stated in
    Cloning and properties of the Caenorhabditis elegans TATA-box-binding protein
    GOA
    curator
    WormBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural basis of preinitiation complex assembly on human pol II promoters
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structural dissection of an interaction between transcription initiation and termination factors implicated in promoter-terminator cross-talk.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Transcription factor IIB acetylates itself to regulate transcription
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The equine herpesvirus 1 EICP27 protein enhances gene expression via an interaction with TATA box-binding protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interaction of the equine herpesvirus 1 EICP0 protein with the immediate-early (IE) protein, TFIIB, and TBP may mediate the antagonism between the IE and EICP0 proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Specific interactions with TBP and TFIIB in vitro suggest that 14-3-3 proteins may participate in the regulation of transcription when part of a DNA binding complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Direct interaction of TFIIB and the IE protein of equine herpesvirus 1 is required for maximal trans-activation function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interaction of the equine herpesvirus 1 EICP0 protein with the immediate-early (IE) protein, TFIIB, and TBP may mediate the antagonism between the IE and EICP0 proteins
    GOA
    curator
    AgBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Direct interaction of TFIIB and the IE protein of equine herpesvirus 1 is required for maximal trans-activation function
    GOA
    curator
    AgBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IPI
    cell component
    protein-DNA complex
    determination method or standard
    IDA
    5 references
    retrieved
    1 January 2018
    stated in
    Structural basis of preinitiation complex assembly on human pol II promoters
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Structural dissection of an interaction between transcription initiation and termination factors implicated in promoter-terminator cross-talk.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Functional dissection of TFIIB domains required for TFIIB-TFIID-promoter complex formation and basal transcription activity
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Potential RNA polymerase II-induced interactions of transcription factor TFIIB.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Functional domains of transcription factor TFIIB.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IDA
    nucleus
    determination method or standard
    IBA
    IDA
    IEA
    6 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IEA
    retrieved
    1 January 2018
    stated in
    Transcription factor IIB acetylates itself to regulate transcription
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Human Protein Atlas
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Oestrogen receptor facilitates the formation of preinitiation complex assembly: involvement of the general transcription factor TFIIB
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IBA
    biological process
    transcription by RNA polymerase II
    determination method or standard
    IMP
    TAS
    9 references
    retrieved
    10 September 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00403&geneProductId=UniProtKB:Q00403
    determination method or standard
    TAS
    retrieved
    10 September 2018
    stated in
    Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00403&geneProductId=UniProtKB:Q00403
    determination method or standard
    TAS
    retrieved
    10 September 2018
    stated in
    Cloning of a human gene encoding the general transcription initiation factor IIB
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00403&geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    10 September 2018
    stated in
    Recycling of the general transcription factors during RNA polymerase II transcription
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00403&geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    10 September 2018
    stated in
    Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00403&geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    10 September 2018
    stated in
    A core promoter element downstream of the TATA box that is recognized by TFIIB.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00403&geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    10 September 2018
    stated in
    Functional dissection of TFIIB domains required for TFIIB-TFIID-promoter complex formation and basal transcription activity
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00403&geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    10 September 2018
    stated in
    Potential RNA polymerase II-induced interactions of transcription factor TFIIB.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00403&geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    10 September 2018
    stated in
    Functional domains of transcription factor TFIIB.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00403&geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    transcription by RNA polymerase II
    determination method or standard
    IDA
    IMP
    TAS
    10 references
    retrieved
    1 January 2018
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein
    GOA
    curator
    Proteome Inc.
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    TAS
    retrieved
    1 January 2018
    stated in
    Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    A core promoter element downstream of the TATA box that is recognized by TFIIB.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    Cloning of a human gene encoding the general transcription initiation factor IIB
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    Functional dissection of TFIIB domains required for TFIIB-TFIID-promoter complex formation and basal transcription activity
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    Recycling of the general transcription factors during RNA polymerase II transcription
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    Potential RNA polymerase II-induced interactions of transcription factor TFIIB.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    Functional domains of transcription factor TFIIB.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q00403
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    Near-atomic resolution visualization of human transcription promoter opening
    GOA
    curator
    ARUK-UCL
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00403
    determination method or standard
    IDA
    Gene Atlas image
    PBB GE GTF2B 208066 s at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

    MeSH descriptor ID
    D035581
    subject named as
    Transcription Factor TFIIB
    0 references
    PDB structure ID
     
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q425812&oldid=2383309146"