Thromboxane (Tx) A2 receptor blockade and TxA2 synthase inhibition alone and in combination: comparison of anti-aggregatory efficacy in human platelets (Q42560642)

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scientific article published on February 1, 1991

Language	Label	Description	Also known as
English	Thromboxane (Tx) A2 receptor blockade and TxA2 synthase inhibition alone and in combination: comparison of anti-aggregatory efficacy in human platelets	scientific article published on February 1, 1991

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scholarly article

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Europe PubMed Central

PMC publication ID

2 November 2017

Thromboxane (Tx) A2 receptor blockade and TxA2 synthase inhibition alone and in combination: comparison of anti-aggregatory efficacy in human platelets (English)

1 reference

10.1111/J.1476-5381.1991.TB12200.X

https://api.crossref.org/works/10.1111/J.1476-5381.1991.TB12200.X

3 December 2022

1 reference

10.1111/J.1476-5381.1991.TB12200.X

https://api.crossref.org/works/10.1111/J.1476-5381.1991.TB12200.X

3 December 2022

author name string

I. S. Watts

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1826620

3 December 2022

K. A. Wharton

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1826620

3 December 2022

B. P. White

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1826620

3 December 2022

P. Lumley

4

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1826620

3 December 2022

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1 February 1991

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2 November 2017

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https://europepmc.org/articles/PMC1918008

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1826620

3 December 2022

https://europepmc.org/articles/PMC1918008?pdf=render

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1826620

3 December 2022

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1476-5381.1991.tb12200.x

1 reference

10.1111/J.1476-5381.1991.TB12200.X

https://api.crossref.org/works/10.1111/J.1476-5381.1991.TB12200.X

3 December 2022

http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1476-5381.1991.tb12200.x/fullpdf

1 reference

10.1111/J.1476-5381.1991.TB12200.X

https://api.crossref.org/works/10.1111/J.1476-5381.1991.TB12200.X

3 December 2022

British Journal of Pharmacology

1 reference

Europe PubMed Central

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2 November 2017

102

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

2

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

497-505

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Some quantitative uses of drug antagonists

1 reference

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Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man.

1 reference

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Potentiation by dazoxiben, a thromboxane synthetase inhibitor, of platelet aggregation inhibitory activity of a thromboxane receptor antagonist and of prostacyclin

1 reference

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Studies on the characterisation of prostanoid receptors: a proposed classification

1 reference

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Inhibition of thromboxane synthetase does not necessarily prevent platelet aggregation

1 reference

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The biochemical pharmacology of thromboxane synthase inhibition in man.

1 reference

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28 May 2018

Prostaglandin endoperoxides modulate the response to thromboxane synthase inhibition during coronary thrombosis

1 reference

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28 May 2018

Thromboxane A2 biosynthesis in human disease

1 reference

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28 May 2018

Interaction of blood platelets with the vessel wall

1 reference

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The thromboxane A2/prostaglandin endoperoxide receptor antagonist activity of CV-4151, a thromboxane A2 synthetase inhibitor

1 reference

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28 May 2018

Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism

1 reference

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28 May 2018

In vivo synthesis of thromboxane and prostacyclin in man in health and disease. Data from GC-MS measurements of major urinary metabolites

1 reference

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28 May 2018

Prostaglandin H2 in human platelet activation: coactivator and substitute for thromboxane A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1918008

28 May 2018

GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro

1 reference

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28 May 2018

AH6809, a prostaglandin DP-receptor blocking drug on human platelets

1 reference

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28 May 2018

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides

1 reference

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28 May 2018

The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs

1 reference

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28 May 2018

Acetylation of prostaglandin synthase by aspirin

1 reference

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28 May 2018

Mechanisms of platelet shape change, aggregation, and release induced by collagen, thrombin, or A23,187

1 reference

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28 May 2018

13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor

1 reference

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28 May 2018

Thromboxane synthase inhibition causes re-direction of prostaglandin endoperoxides to prostaglandin D2 during collagen stimulated aggregation of human platelet rich plasma

1 reference

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16 August 2018

A thromboxane synthetase inhibitor reorients endoperoxide metabolism in whole blood towards prostacyclin and prostaglandin E2

1 reference

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Thromboxane synthase inhibition combined with thromboxane receptor blockade: a step forward in antithrombotic strategy?

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1 December 2018

A method for quantitating platelet aggregation and analyzing drug-receptor interactions on platelets in whole blood in vitro

1 reference

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Platelet interaction with collagen fibrils in flowing blood. I. Reaction of human platelets with alpha chymotrypsin-digested subendothelium

1 reference

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R 68 070: thromboxane A2 synthetase inhibition and thromboxane A2/prostaglandin endoperoxide receptor blockade combined in one molecule--I. Biochemical profile in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/1826620

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CV-4151--a potent, selective thromboxane A2 synthetase inhibitor

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https://pubmed.ncbi.nlm.nih.gov/1826620

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Analysis of multiple thromboxane metabolites in plasma and urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/1826620

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The inhibitory effect of GR32191, a thromboxane receptor blocking drug, on human platelet aggregation, adhesion and secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/1826620

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The response to thromboxane A2 analogues in human platelets. Discrimination of two binding sites linked to distinct effector systems

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Preliminary assessment of a novel thromboxane A2 receptor-blocking drug, GR32191, in healthy subjects

1 reference

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Evidence that prostaglandin endoperoxides can induce platelet aggregation in the absence of thromboxane A2 production

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Administration to man of UK-37,248-01, a selective inhibitor of thromboxane synthetase

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Thromboxane synthetase inhibition as antithrombotic strategy

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A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions

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Preliminary clinical studies with thromboxane synthase inhibitors and thromboxane receptor blockers. A review

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1 reference

10.1111/J.1476-5381.1991.TB12200.X

https://api.crossref.org/works/10.1111/J.1476-5381.1991.TB12200.X

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Pathophysiological actions of thromboxane A2 and their pharmacological antagonism by thromboxane receptor blockade with GR32191

21

1 reference

10.1111/J.1476-5381.1991.TB12200.X

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Maximal blockade of TxA2 without compromised PGI2 formation; a superior profile of the TxA2 receptor blocking drug GR32191 over aspirin

29

1 reference

10.1111/J.1476-5381.1991.TB12200.X

https://api.crossref.org/works/10.1111/J.1476-5381.1991.TB12200.X

3 December 2022

Identifiers

10.1111/J.1476-5381.1991.TB12200.X

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

ResearchGate publication ID

0 references

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