Evaluation of Tet-on system to avoid transgene down-regulation in ex vivo gene transfer to the CNS. (Q42525849)

1 November 2017

Evaluation of Tet-on system to avoid transgene down-regulation in ex vivo gene transfer to the CNS. (English)

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1 November 2017

Johansen J

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1 November 2017

Rosenblad C

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1 November 2017

Andsberg K

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1 November 2017

Møller A

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1 November 2017

Lundberg C

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1 November 2017

Björlund A

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1 November 2017

Johansen TE

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1 November 2017

language of work or name

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1 October 2002

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1 November 2017

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1 November 2017

9

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1 November 2017

1291-1301

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1 November 2017

19

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3301778

1 November 2017

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Gene therapy in the CNS.

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Gene transfer to the central nervous system by transplantation of cerebral endothelial cells.

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Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's disease

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The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice

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Biosynthesis of peptide precursors and protease inhibitors using new constitutive and inducible eukaryotic expression vectors.

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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Lentiviral vectors: regulated gene expression

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Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system

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Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

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Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain

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The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS.

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Survival, integration, and differentiation of neural stem cell lines after transplantation to the adult rat striatum

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A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells

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Improved survival of embryonic porcine dopaminergic neurons in coculture with a conditionally immortalized GDNF-producing hippocampal cell line

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Regulated gene expression systems

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Transcriptional activation by tetracyclines in mammalian cells

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Tetracycline-controlled gene expression system achieves high-level and quantitative control of gene expression

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Repeat-induced gene silencing in mammals.

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A novel tetracycline-dependent expression vector with low basal expression and potent regulatory properties in various mammalian cell lines

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Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo

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Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain.

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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

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High levels of transgene expression following transduction of long-term NOD/SCID-repopulating human cells with a modified lentiviral vector

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The DNA methylation machinery as a target for anticancer therapy

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DNA methylation represses transcription in vivo.

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Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase

21 January 2018

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Long-term expression driven by herpes simplex virus type-1 amplicons may fail due to eventual degradation or extrusion of introduced transgenes

21 January 2018

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Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

21 January 2018

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The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

21 January 2018

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A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

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The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation

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Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle

21 January 2018

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Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat.

21 January 2018

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Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function.

21 January 2018

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7 January 2021

Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis

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7 January 2021

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

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7 January 2021

Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

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7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3301778

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Dimensions Publication ID

1 November 2017

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